Chemistry:2CT4-2-EtO
2CT4-2-EtO, also known as 2-ethoxy-5-methoxy-4-isopropylthiophenethylamine or as Tenderness, is a psychoactive drug of the phenethylamine, 2C, and TWEETIO families related to the psychedelic drug 2C-T-4.[1][2][3] It is the derivative of 2C-T-4 in which the methoxy group at the 2 position has been replaced with an ethoxy group.[1][2][3]
According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CT4-2-EtO's dose is 10 to 25 mg orally and its duration is approximately 10 hours.[1][2][3] Doses between 10 and 25 mg with 5-mg increments resulted in virtually no differences in effects or duration, with a gentle "plus-two" on the Shulgin Rating Scale being reached independently of dose.[1] However, in another publication, Shulgin stated that the dose affected the duration only.[2] The effects of 2CT4-2-EtO have been reported to include "a peaceful meditative inner receptiveness and clarity" and "an honest connection felt with those who were present during the experience".[1][2][3] This resulted in the drug being given the nickname "Tenderness".[1] 2CT4-2-EtO also caused uncomfortable sleep.[1]
The chemical synthesis of 2CT4-2-EtO has been described.[1]
2CT4-2-EtO was first described in the literature by Shulgin in PiHKAL in 1991.[1] It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin.[2][4][5][6][7] The drug is a controlled substance in Canada under phenethylamine blanket-ban language.[8]
See also
- TWEETIO (psychedelics)
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. http://www.erowid.org/library/books_online/pihkal/pihkal.shtml. "The same wide range of effective dosages was also observed with the corresponding Tweetio. The 2-EtO-homologue of 2C-T-4 is 2-ethoxy-5-methoxy-4-isopropylthiophenethylamine, or 2CT4-2ETO. The benzaldehyde (2-ethoxy-5-methoxy-4-(isopropylthio)benzaldehyde) had a melting point of 43–44 °C, the nitrostyrene intermediate a melting point of 77–79 °C, and the final hydrochloride a melting point of 153.5–154 °C. There were practically no differences between trials at 5 milligram increments within the 10 and 25 milligram range. Each produced a gentle plus two level of effect which lasted for some 10 hours. A code name of “tenderness” was felt to be appropriate, as there was a peaceful meditative inner receptiveness and clarity noted, with an honest connection felt with those who were present during the experience. Sleep was not comfortable."
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 "Basic Pharmacology and Effects". Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. 2003. pp. 67–137. ISBN 978-0-12-433951-4. https://bibliography.maps.org/resources/download/12634.
- ↑ 3.0 3.1 3.2 3.3 (in de) Phenethylamine: von der Struktur zur Funktion. Nachtschatten-Science (1 ed.). Solothurn: Nachtschatten-Verlag. 2013. ISBN 978-3-03788-700-4. OCLC 858805226. https://books.google.com/books?id=-Us1kgEACAAJ.
- ↑ "Erowid Darrell Lemaire Vault". https://erowid.org/culture/characters/lemaire_darrell/lemaire_darrell.shtml.
- ↑ Morris H (7 December 2016). "The Lazy Lizard School of Hedonism". Hamilton's Pharmacopeia. Season 1. Episode 6. Vice Media. Viceland.
- ↑ "Notes About Psychoactive Compounds". Radiant Minds: Scientists Explore the Dimensions of Consciousness. Millay. 2010. pp. 201–207. ISBN 978-0-615-29633-3. https://erowid.org/culture/characters/lemaire_darrell/lemaire_darrell_article1.pdf.
- ↑ Certain Exotic Transmitters as Smart Pills or Compounds that Increase the Capacity for Mental Work in Humans: A Story About LAZAR as Told by Hosteen Nez (2nd ed.). 1990. https://erowid.org/chemicals/2cd/2cd_smartpills1.pdf.
- ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html.
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