Chemistry:EMDA-2

From HandWiki

EMDA-2, also known as 2-ethoxy-4,5-methylenedioxyamphetamine, is a psychedelic drug of the phenethylamine and methylenedioxyamphetamine families.[1][2][3] It is the analogue of MMDA-2 in which the 2-methoxy group has been replaced with a 2-ethoxy group.[1][2] This has resulted in EMDA-2 being described as the "TWEETIO" analogue of MMDA-2.[1]

Use and effects

EMDA-2's dose is approximately 135 to 185 mg and its duration is about 10 to 12 hours.[1][2] At 135 mg, it produced closed eye visuals, including intense colors, with sleep disturbances and a duration of some 10 hours.[1] At 185 mg, its effects were stronger, including "marvelous" closed-eye visuals with "incredible" colors, good concentration, and distinct body tingles and rushes, with insomnia and a duration of about 12 hours.[1] The potency of EMDA-2 is about one-third that of MMDA-2.[1]

Interactions

History

EMDA-2 appears to have first been described in the scientific literature by at least 1975.[3] Its effects in humans were described by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).[1][2]

See also

  • Substituted methylenedioxyphenethylamine
  • Methoxymethylenedioxyamphetamine

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. http://www.erowid.org/library/books_online/pihkal/pihkal.shtml.  "The Tweetio homologue of MMDA-2 has been tasted, however. This is 2-ethoxy-4,5-methylenedioxyamphetamine, or EMDA-2. [...] At 135 milligrams, there have been reported eyes-closed visual phenomena, with intense colors. The overall duration is similar to MMDA-2 (some 10 hours) and there are reported sleep disturbances. At 185 milligrams, the feelings were intensified, there were “marvelous eyes-closed visuals (the colors were incredible), good concentration, but distinct body-tingles and rushes.” The time span was about 12 hours from start to finish, but it proved to be impossible to sleep afterwards. This homologue is thus about a third the potency of MMDA-2."
  2. 2.0 2.1 2.2 2.3 (in de) Phenethylamine: von der Struktur zur Funktion. Nachtschatten-Science (1 ed.). Solothurn: Nachtschatten-Verlag. 2013. pp. 828–829. ISBN 978-3-03788-700-4. OCLC 858805226. https://books.google.com/books?id=-Us1kgEACAAJ. Retrieved 31 January 2025. 
  3. 3.0 3.1 "Phenylalkylamines and Their Derivatives". Hallucinogenic Agents. Bristol: Wright-Scientechnica. 1975. pp. 55–97. https://bitnest.netfirms.com/external/Books/978-0-85608-011-1. 


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