Chemistry:HOT-7

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HOT-7, also known as 4-propylthio-2,5-dimethoxy-N-hydroxyphenethylamine or as N-hydroxy-2C-T-7, is a psychedelic drug of the phenethylamine, 2C, and HOT-x families.[1] It is the N-hydroxy derivative of 2C-T-7.[1] The drug is taken orally.[1]

Use and effects

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists HOT-7's dose range as 15 to 20 mg orally and its duration as 6 to 8 hours.[1] The drug's onset and peak of effects were not described.[1] HOT-7's properties are similar to those of 2C-T-7, which has a dose of 10 to 30 mg orally and a duration of 8 to 15 hours, although HOT-7 may have a somewhat shorter duration.[1][2] HOT-7 may act as a prodrug of 2C-T-7.[2]

The effects of HOT-7 have been reported to include being "quite psychedelic", very rich in closed-eye imagery, not as much in terms of open-eye visuals, very good for interpretive and conceptual thinking, emotional changes, feeling "smoothly stoned", lightheadedness, alcohol-like tipsiness and wooziness, social avoidance, and gastrointestinal disturbances.[1]

Interactions

Chemistry

Synthesis

The chemical synthesis of HOT-7 has been described.[1]

Analogues

Analogues of HOT-7 include 2C-T-7, HOT-2 (N-hydroxy-2C-T-2), and HOT-17 (N-hydroxy-2C-T-17), among others.[1]

History

HOT-7 was first described in the literature by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).[1]

Society and culture

Canada

HOT-7 is a controlled substance in Canada under phenethylamine blanket-ban language.[3]

United Kingdom

This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act.[4]

See also

  • HOT-x (psychedelics)

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252. http://www.erowid.org/library/books_online/tihkal/tihkal.shtml.  [1]
  2. ↑ 2.0 2.1 Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. http://www.erowid.org/library/books_online/pihkal/pihkal.shtml.  https://www.erowid.org/library/books_online/pihkal/pihkal081.shtml "I first observed the intimate connection between an amine and a hydroxylamine with the discovery that N-hydroxy-MDA (MDOH) was equipotent and of virtually identical activity to the non-hydroxylated counterpart (MDA). And I have speculated in the recipe for MDOH about the possible biological interconversions of these kinds of compounds. And here, the simple addition of a hydroxyl group to the amine nitrogen atom of MDMA produces a new drug that is in most of its properties identical to MDMA. The concept has been extended to 2C-T-2, 2C-T-7, and 2C-T-17, where each of these three active compounds was structurally modified in exactly this way, by the addition of a hydroxyl group to the amine nitrogen atom. The results, HOT-2, HOT-7 and HOT-17 were themselves all active, and compared very closely with their non-hydroxylated prototypes."
  3. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 
  4. ↑ "UK Misuse of Drugs act 2001 Amendment summary". Isomer Design. http://isomerdesign.com/Cdsa/scheduleUK.php?schedule=1&ion=30&structure=C. 



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