Chemistry:Thioproscaline
Thioproscaline (TP), or 4-thioproscaline (4-TP'), also known as 3,5-dimethoxy-4-propylthiophenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline.[1][2][3][4] It is the analogue of proscaline in which the propoxy group at the 4 position has been replaced with a propylthio group.[1][2][3]
In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists thioproscaline's dose as 20 to 25 mg orally and its duration as 10 to 15 hours.[1][2][3] Its onset is more than 2 hours.[1] The drug has approximately 10 to 16 times the potency of mescaline.[2][3][4][1] The effects of thioproscaline have been reported to include extremely rich closed-eye imagery, quite a bit of open-eye visuals, body load, body heaviness, heavy pressure at the back of the neck, feeling vulnerable, dizziness, and hyperreflexia.[1][4] It was remarked that the psychoactive effects did not seem worth the physical side effects, although it was suggested that lower doses might be better.[1][4]
The chemical synthesis of thioproscaline has been described.[1][4]
Thioproscaline was first described in the scientific literature by Alexander Shulgin and Peyton Jacob III in 1984.[4] Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.[1] The drug is not a controlled substance in Canada as of 2025.[5]
See also
- Scaline
- 4-Thiomescaline
- 4-Thioescaline
- Thiobuscaline
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. http://www.erowid.org/library/books_online/pihkal/pihkal.shtml. https://www.erowid.org/library/books_online/pihkal/pihkal174.shtml
- ↑ 2.0 2.1 2.2 2.3 "Structure-Activity Relationships of the Classic Hallucinogens and Their Analogs". Hallucinogens: An Update. National Institute on Drug Abuse Research Monograph Series. 146. National Institute on Drug Abuse. 1994. pp. 74–91. https://bibliography.maps.org/resources/download/11534.
- ↑ 3.0 3.1 3.2 3.3 "Basic Pharmacology and Effects". Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. 2003. pp. 67–137. ISBN 978-0-12-433951-4. https://bibliography.maps.org/resources/download/12634.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 "Sulfur analogues of psychotomimetic agents. 3. Ethyl homologues of mescaline and their monothio analogues". J Med Chem 27 (7): 881–888. July 1984. doi:10.1021/jm00373a013. PMID 6737431.
- ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html.
External links
- Thioproscaline - Isomer Design
- Thioproscaline - PiHKAL - Erowid
- Thioproscaline - PiHKAL - Isomer Design
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