Chemistry:GLPG-0492
From HandWiki
Short description: Medication
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| Formula | C19H14F3N3O3 |
| Molar mass | 389.334 g·mol−1 |
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GLPG-0492 (DT-200) is a drug which acts as a selective androgen receptor modulator (SARM). It has been investigated for the treatment of cachexia and muscular dystrophy.[1][2][3][4][5][6]
See also
References
- ↑ "Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulator". Journal of Medicinal Chemistry 55 (19): 8236–8247. October 2012. doi:10.1021/jm300281x. PMID 22957947.
- ↑ "GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy". Pharmacological Research 72: 9–24. June 2013. doi:10.1016/j.phrs.2013.03.003. PMID 23523664.
- ↑ "Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization". BMC Musculoskeletal Disorders 15: 291. September 2014. doi:10.1186/1471-2474-15-291. PMID 25185887.
- ↑ "Comparison of the three SARMs RAD-140, GLPG0492 and GSK-2881078 in two different in vitro bioassays, and in an in silico androgen receptor binding assay". The Journal of Steroid Biochemistry and Molecular Biology 189: 81–86. May 2019. doi:10.1016/j.jsbmb.2019.02.014. PMID 30825507.
- ↑ "Selective androgen receptor modulators (SARMs) as pharmacological treatment for muscle wasting in ongoing clinical trials". Expert Opinion on Investigational Drugs 29 (8): 881–891. August 2020. doi:10.1080/13543784.2020.1777275. PMID 32476495.
- ↑ "Simultaneous detection of different chemical classes of selective androgen receptor modulators in urine by liquid chromatography-mass spectrometry-based techniques". Journal of Pharmaceutical and Biomedical Analysis 195: 113849. February 2021. doi:10.1016/j.jpba.2020.113849. PMID 33383501.
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