Chemistry:5-APB-NBOMe

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5-APB-NBOMe, also known as N-(2-methoxybenzyl)-5-(2-aminopropyl)benzofuran, is a drug of the phenethylamine, amphetamine, benzofuran, and 25-NB (NBOMe) families related to the entactogen and mildly psychedelic drug 5-APB.[1][2][3] It is the N-(2-methoxybenzyl) derivative of 5-APB.[4][5][3] The preclinical pharmacokinetics of 5-APB-NBOMe have been studied.[4] The drug was encountered as a novel designer drug in Germany in 2014.[2][6][4][5]

See also

References

  1. ↑ "Psychonauts' psychedelics: A systematic, multilingual, web-crawling exercise". European Neuropsychopharmacology 49: 69–92. August 2021. doi:10.1016/j.euroneuro.2021.03.006. PMID 33857740. 
  2. ↑ 2.0 2.1 "Pharmacology and toxicology of N-Benzyl-phenylethylamines (25X-NBOMe) hallucinogens". Novel Psychoactive Substances. Elsevier. 2022. pp. 279–300. doi:10.1016/b978-0-12-818788-3.00008-5. ISBN 978-0-12-818788-3. https://linkinghub.elsevier.com/retrieve/pii/B9780128187883000085. Retrieved 8 January 2026. "The newest 25X-NBOMes to be identified include 3,4-dimethoxyamphetamine (3,4-DMA)- NBOMe [34,46], 4-methylmethamphetamine (4-MMA)-NBOMe [34,46], N‐(ortho‐methoxybenzyl)‐4‐ethylamphetamine (4‐EA‐NBOMe) [34,46] and N‐(ortho‐methoxybenzyl)‐5‐(2‐aminopropyl)benzofuran (5‐APB‐NBOMe) [34,46], which were identified in Germany in 2015.The relatively novel compounds 25H—NBOMe, 25D-NBOMe and 25E-NBOMe were identified in Japan in 2016 [47]." 
  3. ↑ 3.0 3.1 "In vitro toxicokinetics and analytical toxicology of three novel NBOMe derivatives: phase I and II metabolism, plasma protein binding, and detectability in standard urine screening approaches studied by means of hyphenated mass spectrometry". Forensic Toxicology 38 (1): 141–159. 2020. doi:10.1007/s11419-019-00498-7. ISSN 1860-8965. http://link.springer.com/10.1007/s11419-019-00498-7. Retrieved 8 January 2026. 
  4. ↑ 4.0 4.1 4.2 "Analytical characterization of four new ortho-methoxybenzylated amphetamine-type designer drugs". Drug Testing and Analysis 8 (9): 910–919. September 2016. doi:10.1002/dta.1889. PMID 26606897. 
  5. ↑ 5.0 5.1 "Identification of five substituted phenethylamine derivatives 5-MAPDB, 5-AEDB, MDMA methylene homolog, 6-Br-MDMA, and 5-APB-NBOMe". Drug Testing and Analysis 9 (2): 199–207. February 2017. doi:10.1002/dta.1955. PMID 26856255. 
  6. ↑ "EMCDDA–Europol 2014 Annual Report on the implementation of Council Decision". European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). https://isomerdesign.com/bitnest/external/EMCDDA/New-Drugs-In-Europe-2014. 



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