Chemistry:5-Thiometaescaline
5-Thiometaescaline (5-TME), also known as 3-ethoxy-4-methoxy-5-methylthiophenethylamine, is a psychoactive drug of the phenethylamine and scaline families related to mescaline.[1][2][3] It is the analogue of metaescaline in which the methoxy group at the 5 position has been replaced with a methylthio group.[1][2][3] The drug is one of three possible positional isomers of thiometaescaline (TME), the others being 3-thiometaescaline (3-TME) and 4-thiometaescaline (4-TME).[1][2][3]
In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 5-TME's dose as greater than 200 mg orally and its duration as unknown.[1][2] The effects of 5-TME have been reported to include possible tinnitus, a possible brush of lightheadedness, and nothing else, but these changes could not be clearly ascribed to the drug.[1]
The chemical synthesis of 5-TME has been described.[1][3]
5-TME was first described in the scientific literature by Alexander Shulgin and Peyton Jacob III in 1984.[3] Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.[1]
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. http://www.erowid.org/library/books_online/pihkal/pihkal.shtml. https://www.erowid.org/library/books_online/pihkal/pihkal165.shtml
- ↑ 2.0 2.1 2.2 2.3 "Basic Pharmacology and Effects". Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. 2003. pp. 67–137. ISBN 978-0-12-433951-4. https://bibliography.maps.org/resources/download/12634.
- ↑ 3.0 3.1 3.2 3.3 3.4 "Sulfur analogues of psychotomimetic agents. 3. Ethyl homologues of mescaline and their monothio analogues". J Med Chem 27 (7): 881–888. July 1984. doi:10.1021/jm00373a013. PMID 6737431.
External links
- 5-TME (5-Thiometaescaline) - Isomer Design
- 5-TME (5-Thiometaescaline) - PiHKAL - Erowid
- 5-TME (5-Thiometaescaline) - PiHKAL - Isomer Design
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