Chemistry:6-Hydroxydopa
From HandWiki
6-Hydroxydopa (6-OH-DOPA; 6-OHDOPA) is a catecholaminergic neurotoxin that damages noradrenergic and dopaminergic neurons and is used in scientific research.[1][2][3] It is a precursor and prodrug of 6-hydroxydopamine (6-OHDA).[1][2][3] The drug is a derivative of levodopa (L-DOPA).[1][2][3] It has certain advantages over 6-OHDA, such as the ability to cross the blood–brain barrier into the central nervous system and hence the ability to be administered systemically rather than directly into the brain.[1][2][3] 6-OH-DOPA was first described in the scientific literature by 1969.[4]
References
- ↑ 1.0 1.1 1.2 1.3 "Survey of Selective Monoaminergic Neurotoxins Targeting Dopaminergic, Noradrenergic, and Serotoninergic Neurons". Handbook of Neurotoxicity. Cham: Springer International Publishing. 2022. pp. 159–198. doi:10.1007/978-3-031-15080-7_53. ISBN 978-3-031-15079-1.
- ↑ 2.0 2.1 2.2 2.3 "Perinatal Lesioning and Lifelong Effects of the Noradrenergic Neurotoxin 6-Hydroxydopa". Current Topics in Behavioral Neurosciences. 29. 2016. pp. 43–50. doi:10.1007/7854_2015_414. ISBN 978-3-319-34134-7.
- ↑ 3.0 3.1 3.2 3.3 "Destruction of catecholamine-containing neurons by 6-hydroxydopa, an endogenous amine oxidase cofactor". Amino Acids 14 (1–3): 175–179. 1998. doi:10.1007/BF01345259. PMID 9871458.
- ↑ "The synthesis of 2,4,5-trihydroxyphenylalanine (6-hydroxydopa). A centrally active norepinephrine-depleting agent". Journal of Medicinal Chemistry 12 (3): 458–462. May 1969. doi:10.1021/jm00303a028. PMID 5788162.
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