Chemistry:CYM51010

From HandWiki

CYM51010 is an opioid drug which acts as a selective agonist for the μOR-δOR heteromer, with little affinity for the normal form of the mu opioid receptor or delta opioid receptor. It has analgesic effects but with a reduced side effect profile compared to typical mu opioid agonists.[1][2][3][4][5][6]

See also

  • TAN-821

References

  1. ↑ "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proceedings of the National Academy of Sciences of the United States of America 110 (29): 12072–12077. July 2013. doi:10.1073/pnas.1222044110. PMID 23818586. Bibcode: 2013PNAS..11012072G. 
  2. ↑ "Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon". Cellular and Molecular Gastroenterology and Hepatology 9 (3): 465–483. 2020. doi:10.1016/j.jcmgh.2019.11.006. PMID 31759144. 
  3. ↑ "Activation of µ-δ opioid receptor heteromers inhibits neuropathic pain behavior in rodents". Pain 161 (4): 842–855. April 2020. doi:10.1097/j.pain.0000000000001768. PMID 31815916. 
  4. ↑ "Heteromerization of Endogenous Mu and Delta Opioid Receptors Induces Ligand-Selective Co-Targeting to Lysosomes". Molecules 25 (19): 4493. September 2020. doi:10.3390/molecules25194493. PMID 33007971. 
  5. ↑ "Activation of the Mu-Delta Opioid Receptor Heteromers Blocks Morphine Rewarding Effects". The International Journal of Neuropsychopharmacology 26 (7): 513–521. July 2023. doi:10.1093/ijnp/pyad032. PMID 37343217. 
  6. ↑ "Structure-Activity Relationship Study of CYM51010, an agonist for the µ-δ Opioid Receptor Heterodimer". Chemical & Pharmaceutical Bulletin 72 (7): 711–730. 2024. doi:10.1248/cpb.c24-00188. PMID 39085079. 



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