Chemistry:NNC 63-0532
From HandWiki
Short description: Chemical compound
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| Other names | NNC 63-0532 |
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| Formula | C27H29N3O3 |
| Molar mass | 443.547 g·mol−1 |
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NNC 63-0532 is a nociceptoid drug used in scientific research. It acts as a potent and selective agonist for the nociceptin receptor, also known as the ORL-1 (opiate receptor-like 1) receptor.[1][2]
The function of this receptor is still poorly understood, but it is thought to have roles in many disorders such as pain, drug addiction, development of tolerance to opioid drugs, and psychological disorders such as anxiety and depression. Research into the function of this receptor is an important focus of current pharmaceutical development, and selective agents such as NNC 63-0532 are essential for this work.[3]
References
- ↑ "(8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4. 5dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist"]. British Journal of Pharmacology 131 (5): 903–8. November 2000. doi:10.1038/sj.bjp.0703661. PMID 11053209.
- ↑ "Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity". The Journal of Peptide Research 63 (6): 477–84. June 2004. doi:10.1111/j.1399-3011.2004.00157.x. PMID 15175020.
- ↑ "Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications". Current Drug Targets 8 (1): 117–35. January 2007. doi:10.2174/138945007779315605. PMID 17266536.
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