Chemistry:Asimadoline
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Short description: Chemical compound
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| Other names | EMD-61753 |
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| Formula | C27H30N2O2 |
| Molar mass | 414.549 g·mol−1 |
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Asimadoline (EMD-61753) is an experimental drug which acts as a peripherally selective κ-opioid receptor (KOR) agonist.[1][2] Because of its low penetration across the blood–brain barrier, asimadoline lacks the psychotomimetic effects of centrally acting KOR agonists, and consequently was thought to have potential for medical use. It has been studied as a possible treatment for irritable bowel syndrome, with reasonable efficacy seen in clinical trials,[3][4] but it has never been approved or marketed.
See also
References
- ↑ "Novel developments with selective, non-peptidic kappa-opioid receptor agonists". Expert Opinion on Investigational Drugs 6 (10): 1351–68. October 1997. doi:10.1517/13543784.6.10.1351. PMID 15989506.
- ↑ Camilleri M (September 2008). "Novel pharmacology: asimadoline, a kappa-opioid agonist, and visceral sensation". Neurogastroenterology & Motility 20 (9): 971–9. doi:10.1111/j.1365-2982.2008.01183.x. PMID 18715494.
- ↑ "Effect of asimadoline, a kappa opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome". Alimentary Pharmacology & Therapeutics 20 (2): 237–46. July 2004. doi:10.1111/j.1365-2036.2004.01922.x. PMID 15233705.
- ↑ "Efficacy of on-demand asimadoline, a peripheral kappa-opioid agonist, in females with irritable bowel syndrome". Clinical Gastroenterology and Hepatology 5 (11): 1268–75. November 2007. doi:10.1016/j.cgh.2007.07.011. PMID 17900994.
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