Chemistry:List of opioids
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This is a list of opioids, opioid antagonists and inverse agonists.
Opium and poppy straw derivatives
Crude opiate extracts whole opium products
- B&O Supprettes
- Diascordium
- Dover's powder
- Kendal Black Drop
- Laudanum
- Mithridate
- Opium
- Polish heroin (Compote, Kompot)
- Paregoric
- Poppy straw concentrate
- Poppy tea
- Smoking opium
- Theriac
Natural opiates
Opium alkaloids
Structures
Morphides | ||||
---|---|---|---|---|
Codeine | Morphine | Oripavine | Pseudomorphine | Thebaine |
Alkaloid salts mixtures
- Pantopon
- Papaveretum (Omnopon)
- Tetrapon
Semisynthetics including Bentley compounds
Morphine family
- 14-Hydroxymorphine [1]
- 2,4-Dinitrophenylmorphine
- 6-Methyldihydromorphine [2]
- 6-Methylenedihydrodesoxymorphine
- 6-Acetyldihydromorphine [3]
- Azidomorphine
- Chlornaltrexamine
- Chloroxymorphamine [4]
- Desomorphine (dihydrodesoxymorphine)
- Dihydromorphine
- Ethyldihydromorphine [5][full citation needed]
- Hydromorphinol
- Methyldesorphine
- Morphine methylbromide
- N-Phenethylnordesomorphine
- N-Phenethyl-14-ethoxymetopon
- N-Phenethylnormorphine
- 6-Nicotinoyldihydromorphine (metabolite of nicodicodeine)
- RAM-378
- Ro-1539
Structures of Morphine family
Morphine family | ||||
---|---|---|---|---|
14-Hydroxymorphine | 2,4-Dinitrophenylmorphine | 6-Methyldihydromorphine | 6-Methylenedihydrodesoxymorphine | 6-Acetyldihydromorphine hydrochloride |
Azidomorphine | Chlornaltrexamine | Chloroxymorphamine | Desomorphine (Dihydrodesoxymorphine) |
Dihydromorphine |
Ethyldihydromorphine | Hydromorphinol | Methyldesorphine | N-Phenethylnormorphine | 6-nicotinoyldihydromorphine |
RAM-378 | ||||
3,6-diesters of morphine
- Acetylpropionylmorphine
- 3,6-Dibutanoylmorphine
- Diacetyldihydromorphine (dihydroheroin, acetylmorphinol)
- Dibutyrylmorphine [1]
- Dibenzoylmorphine (first designer drug)
- Diformylmorphine
- Dipropanoylmorphine
- Heroin (diacetylmorphine)
- Nicomorphine
Structures
3,6-diesters of morphine | ||||
---|---|---|---|---|
Acetylpropionylmorphine | 3,6-Dibutanoylmorphine | Diacetyldihydromorphine (dihydroheroin, acetylmorphinol) | ||
Dibutyrylmorphine | Dibenzoylmorphine | Diformylmorphine | ||
Dipropanoylmorphine | Heroin (diacetylmorphine) |
Nicomorphine |
Codeine-dionine family
- 6-Monoacetylcodeine
- Benzylmorphine
- Codeine methylbromide
- Desocodeine [2] [yes|permanent dead link|dead link}}]
- Dimethylmorphine (6-O-Methylcodeine)
- Ethyldihydromorphine [3] [yes|permanent dead link|dead link}}]
- Methyldihydromorphine (dihydroheterocodeine)
- Ethylmorphine (dionine)
- Heterocodeine
- Isocodeine [4]
- Pholcodine (morpholinylethylmorphine)
- Myrophine
- Thebacon
- Transisocodeine [5]
Structures
Codeine-dionine family | ||||
---|---|---|---|---|
6-Monoacetylcodeine | Benzylmorphine | Codeine methylbromide | Desocodeine | Dimethylmorphine (6-O-Methylcodeine) |
Ethyldihydromorphine | Methyldihydromorphine (dihydroheterocodeine) |
Ethylmorphine | Heterocodeine | Isocodeine |
Pholcodine | Myrophine | Transisocodeine | ||
Morphinones and morphols
- 14-Cinnamoyloxycodeinone
- 14-Ethoxymetopon
- 14-Methoxymetopon
- 14-Phenylpropoxymetopon
- 3-Acetyloxymorphone
- 3,14-Diacetyloxymorphone
- 7-Spiroindanyloxymorphone
- 8,14-Dihydroxydihydromorphinone [6]
- Acetylcodone
- Acetylmorphone
- α-hydrocodol (=dihydrocodeine, )
- Benzhydrocodone
- Bromoisopropropyldihydromorphinone cas?
- Codeinone
- Codoxime
- Conorfone (codorphone)
- IBNtxA
- Thebacon (acetyldihydrocodeinone, dihydrocodeinone enol acetate)
- Hydrocodone
- Hydromorphone
- Hydroxycodeine [7]
- Metopon (=methyldihydromorphinone)
- Morphenol [8]
- Morphinone
- Morphol [9]
- N-Phenethyl-14-ethoxymetopon
- Noroxymorphone
- Oxycodone
- Oxymorphol
- Oxymorphone
- Pentamorphone
- Semorphone
Structures
Morphinones and morphols | ||||
---|---|---|---|---|
14-Cinnamoyloxycodeinone | 14-Ethoxymetopon | 14-Methoxymetopon | 14-Phenylpropoxymetopon | 7-Spiroindanyloxymorphone |
8,14-Dihydroxydihydromorphinone | Acetylcodone | Acetylmorphone | α-hydrocodol (Dihydrocodeine) |
Bromoisopropropyldihydromorphinone |
Codeinone | Codorphone | Codol (Codeine Phosphate) |
Codoxime | IBNtxA |
Thebacon | Hydrocodone | Hydromorphone | Hydroxycodeine | Metopon (methyldihydromorphinone) |
Morphenol | Morphinone | Morphol | N-Phenethyl-14-ethoxymetopon | Oxycodone |
Oxymorphol | Oxymorphone | Pentamorphone | Semorphone |
Morphides
- α-Chlorocodide (= chlorocodide) [10]
- β-Chlorocodide [11]
- α-Chloromorphide (= chloromorphide)
- Bromocodide [12]
- Bromomorphide [13]
- Chlorodihydrocodide [14]
- Chloromorphide
- Codide [15]
Structures
Morphides | ||||
---|---|---|---|---|
α-chlorocodide | β-chlorocodide | Bromomorphide | ||
Chlorodihydrocodide. | Chloromorphide | Codide | ||
Dihydrocodeine series
- 14-Hydroxydihydrocodeine
- Acetyldihydrocodeine
- Dihydrocodeine
- Dihydrodesoxycodeine (desocodeine)
- Dihydroisocodeine
- Nicocodeine
- Nicodicodeine
Structures
Morphides | ||||
---|---|---|---|---|
14-Hydroxydihydrocodeine | Acetyldihydrocodeine | Dihydrocodeine | Dihydrodesoxycodeine | |
Dihydroisocodeine | Nicocodeine | Nicodicodeine |
Nitrogen morphine derivatives
- 1-Nitrocodeine cas? [16]
- Codeine-N-oxide [17]
- Morphine-N-oxide
Structures
Morphides | ||||
---|---|---|---|---|
1-Nitrocodeine | Codeine-N-oxide | Morphine-N-oxide |
Hydrazones
Structures
Hydrazones | ||||
---|---|---|---|---|
Oxymorphazone |
Halogenated morphine derivatives
- 1-Bromocodeine
- 1-Chlorocodeine
- 1-Iodomorphine
Active opiate metabolites
- Codeine-6-glucuronide
- Codeine-N-oxide (genocodeine)[18]
- Heroin-7,8-oxide [19]
- Morphine-6-glucuronide
- 3-Monoacetylmorphine
- 6-Monoacetylmorphine
- Morphine-N-oxide (genomorphine)
- Naltrexol [20]
- Norcodeine
- Normorphine
Structures
Active opiate metabolites | ||||
---|---|---|---|---|
Codeine-N-oxide | Heroin-7,8-oxide | Morphine-6-glucuronide | 6-Monoacetylmorphine | |
Morphine-N-oxide | Naltrexol | Norcodeine | Normorphine | |
Morphinans
Morphinan series
- 3-Hydroxymorphinan
- 4-Chlorophenylpyridomorphinan [21]
- Cyclorphan
- Levargorphan [22]
- Levorphanol
- Levophenacylmorphan
- Levomethorphan
- Methorphan (racemethorphan)
- Morphanol (racemorphanol)
- Norlevorphanol
- N-Methylmorphinan [23]
- Oxilorphan
- Phenomorphan
- Proxorphan
- Ro4-1539
- Stephodeline [24] [yes|permanent dead link|dead link}}]Xorphanol
Structures
Other morphinans | ||||
---|---|---|---|---|
4-chlorophenylpyridomorphinan | Cyclorphan | Dextrallorphan | Levargorphan | Levophenacylmorphan |
Levomethorphan | Norlevorphanol | N-Methylmorphinan | Oxilorphan | Phenomorphan |
Dextromethorphan 70 px|Chemical structure of Levomethorphan. levomethorphan | Morphanol | Ro4-1539 | Stephodeline | Xorphanol |
Others
- 1-Nitroaknadinine * 14-episinomenine
- 5,6-Dihydronorsalutaridine
- 6-Keto Nalbuphine
- Aknadinine
- Butorphanol
- Cephakicine
- Cephasamine
- Cyprodime
- Drotebanol
- Fenfangjine G
- Ketorfanol
- Nalbuphine
- Nalbuphone
- Tannagine
Structures
Other Morphinans | ||||
---|---|---|---|---|
1-Nitroaknadinine | 14-episinomenine | 5,6-Dihydronorsalutaridine | 6-Keto Nalbuphine | Aknadinine |
Butorphanol | Cephakicine | Cephasamine | Cyprodime | Drotebanol |
Fenfangjine G | Nalbuphine | Sinococuline | Sinomenine | Tannagine |
Benzomorphans
- 5,9 alpha-diethyl-2-hydroxybenzomorphan (5,9-DEHB) [25]
- 8-Carboxamidocyclazocine (8-CAC)
- Alazocine
- Anazocine [26]
- Bremazocine
- Butinazocine [27]
- Carbazocine [28]
- Cogazocine
- Cyclazocine
- Dezocine
- Eptazocine
- Etazocine [29] [yes|permanent dead link|dead link}}]
- Ethylketazocine [30]
- Fedotozine
- Fluorophen [31]
- Gemazocine [32] [yes|permanent dead link|dead link}}]
- Ibazocine [33] [yes|permanent dead link|dead link}}]
- Ketazocine
- Metazocine
- Moxazocine [34]
- Pentazocine
- Phenazocine
- Quadazocine [35]
- SKF-10047
[36]-->
Structures
Benzomorphans | ||||
---|---|---|---|---|
5,9 alpha-diethyl-2-hydroxybenzomorphan (5,9-DEHB) |
8-Carboxamidocyclazocine | Alazocine | Anazocine | Bremazocine |
Butinazocine | Carbazocine | Cogazocine | Cyclazocine | Dezocine |
Eptazocine | Etazocine | Ethylketocyclazocine | Fedotozine | Fluorophen |
Gemazocine | Ibazocine | Ketazocine | Metazocine | Moxazocine |
Pentazocine | Phenazocine | Quadazocine | Thiazocine | Tonazocine |
Volazocine | Zenazocine |
4-Phenylpiperidines
Pethidines (meperidines)
- 4-Fluoropethidine
- Allylnorpethidine
- Anileridine
- Benzethidine
- Carperidine
- Difenoxin
- Diphenoxylate
- Etoxeridine (carbetidine)
- Furethidine
- Hydroxypethidine (bemidone)
- Morpheridine
- Meperidine-N-oxide
- Oxpheneridine (carbamethidine)
- Pethidine (meperidine)
- Pethidine intermediate A
- Pethidine intermediate B (norpethidine)
- Pethidine intermediate C (pethidinic acid)
- Pheneridine
- Phenoperidine
- Piminodine
- Properidine (ipropethidine)
- Sameridine
Structures
Pethidines (meperidines) | ||||
---|---|---|---|---|
4-Fluoropethidine | 8-Carboxamidocyclazocine | Allylnorpethidine | Anileridine | Benzethidine |
Carperidine | Difenoxin | Diphenoxylate | Etoxeridine | Furethidine |
Hydroxypethidine | Morpheridine | Meperidine-N-oxide | Oxpheneridine | Pethidine |
Pethidine intermediate A | Pethidine intermediate B | Pethidine intermediate C | Pheneridine | Phenoperidine |
Piminodine | Properidine | Sameridine |
Prodines
- Allylprodine
- (α/β)-Meprodine
- Desmethylprodine (MPPP)
- PEPAP
- (α/β)-Prodine
- Prosidol
- Trimeperidine (promedol)
Structures
Ketobemidones
Structures
Others
Structures
Other phenylpiperidines | |||
---|---|---|---|
Alvimopan | Loperamide | LS-115509 | Picenadol |
Open chain opioids
Amidones
- Dextromethadone
- Dipipanone
- Isomethadone=
- Levoisomethadone
- Levomethadone
- Methadone
- Methadone intermediate [38]
- Normethadone
- Norpipanone [39]
- Phenadoxone (heptazone)
Structures
Amidones | ||||
---|---|---|---|---|
Levoisomethadone | ||||
Noracetylmethadol | Levomethadone | Methadone | Methadone intermediate | |
Normethadone | Norpipanone | Phenadoxone | Pipidone | |
Methadols
- Acetylmethadol
- Alphaacetylmethadol
- Alphamethadol
- Betacetylmethadol
- Betamethadol
- Dimepheptanol (racemethadol)
- Isomethadol
- Levacetylmethadol
- Noracymethadol
Moramides
Thiambutenes
- Diethylthiambutene
- Dimethylthiambutene
- Ethylmethylthiambutene
- Piperidylthiambutene
- Pyrrolidinylthiambutene
- Thiambutene
Phenalkoxams
- Dextropropoxyphene (propoxyphene)
- Dimenoxadol
- Dioxaphetyl butyrate
- Levopropoxyphene
- Norpropoxyphene
- Pyrroliphene
Structures
Phenalkoxams | ||||
---|---|---|---|---|
Dextropropoxyphene |
||||
Ampromides
Others
Anilidopiperidines
- 3-Allylfentanyl
- 3-Methylfentanyl
- 3-Methylthiofentanyl
- 4-Phenylfentanyl
- Alfentanil
- α-Methylacetylfentanyl
- α-Methylfentanyl
- α-Methylthiofentanyl
- Benzylfentanyl [41]
- β-hydroxyfentanyl
- β-hydroxythiofentanyl
- β-Methylfentanyl
- Brifentanil
- Butyrfentanyl
- Carfentanil
- Fentanyl
- Lofentanil
- N-Methylcarfentanil
- Mirfentanil
- Ocfentanil
- Ohmefentanyl
- Parafluorofentanyl
- Phenaridine
- R-30490
- Remifentanil
- Sufentanil
- Thenylfentanyl [42]
- Thiofentanyl
- Trefentanil
Structures
Anilidopiperidines | ||||
---|---|---|---|---|
3-Allylfentanyl | 3-Methylfentanyl | 3-Methylthiofentanyl | 4-Phenylfentanyl | Alfentanil |
Alphamethylacetylfentanyl | Alphamethylfentanyl | Alphamethylthiofentanyl | Benzylfentanyl | Betahydroxyfentanyl |
Betahydroxythiofentanyl | Betamethylfentanyl | Brifentanil | Carfentanil | Fentanyl |
Lofentanil | Mirfentanil | Ocfentanil | Ohmefentanyl | Parafluorofentanyl |
Phenaridine | Remifentanil | Sufentanil | Thenylfentanyl | Thiofentanyl |
Trefentanil |
Oripavine derivatives
- 7-PET
- Acetorphine
- Alletorphine (N-allyl-noretorphine)
- BU-48
- Buprenorphine
- Buprenorphine-3-glucuronide
- Cyprenorphine
- Dihydroetorphine
- Etorphine
- Homprenorphine
- 18,19-Dehydrobuprenorphine (HS-599) [43] [44]
- N-cyclopropylmethylnoretorphine [45]
- Nepenthone [46] [47]
- Norbuprenorphine
- Norbuprenorphine-3-glucuronide
- Thevinone [48]
- Thienorphine [49]
Structures
Oripavine derivatives | ||||
---|---|---|---|---|
7-PET | Acetorphine | Alletorphine | BU-48 | Buprenorphine |
Cyprenorphine | Dihydroetorphine | Etorphine | Homprenorphine | 18,19-Dehydrobuprenorphine |
N-cyclopropylmethylnoretorphine | Nepenthone | Norbuprenorphine | Thevinone | Thienorphine |
Phenazepanes
Pirinitramides
Benzimidazoles
Structures
Benzimidazoles | ||||
---|---|---|---|---|
Nitazene: R = hydrogen | ||||
Indoles
- 18-Methoxycoronaridine
- 7-Acetoxymitragynine
- 7-Hydroxymitragynine
- ψ-Akuammigine
- Akuammidine
- Akuammine
- Coronaridine
- Eseroline
- Hodgkinsine
- Ibogaine
- Mitragynine
- Mitragynine pseudoindoxyl
- Noribogaine
- Pericine
- Pseudoakuammigine
Beta-Amino Ketones
- 3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one
Structures
Diphenylmethylpiperazines
Opioid peptides
Dynorphins
Structures
Dynorphins | ||||
---|---|---|---|---|
Big dynorphin | Dynorphin A | Dynorphin B | ||
Endomorphins
Endorphins
- α-Endorphin
- β-Endorphin
- γ-Endorphin
- α-Neoendorphin
- β-Neoendorphin
Enkephalins
Structures
Enkephalins | ||||
---|---|---|---|---|
DADLE | DAMGO | Deltorphin | Met-enkephalin | Leu-enkephalin |
Propeptides
- Proenkephalin
- Proendorphin
- Proopiomelanocortin
Others / unknown
- Adrenorphin
- Amidorphin
- Biphalin
- Casokefamide
- Casomorphins
- Cytochrophin-4
- DALDA (Tyr-D-Arg-Phe-Lys-NH2)[50]
- Deltorphin I
- Deltorphin II
- Deprolorphin
- Dermorphin
- DPDPE
- Frakefamide
- Gliadorphin
- Gluten exorphins
- Hemorphin-4
- Metkefamide
- Morphiceptin
- Nociceptin
- Octreotide
- Opiorphin
- Rubiscolin
- Soymorphins
- Spinorphin
- TRIMU 5
- Tynorphin
- Valorphin
- Zyklophin
Structures
Other or unknown opioid peptides | ||||
---|---|---|---|---|
Adrenorphin | Amidorphin | Casomorphin | DALDA | Deltorphin |
Dermorphin | DPDPE | Endomorphin-1 135 px|Chemical structure of Endomorphin-2. Endomorphin-2 |
Gliadorphin | Morphiceptin |
Nociceptin | Octreotide | Opiorphin | Rubiscolin | TRIMU 5 |
Others
- 3-(3-Methoxyphenyl)-3-ethoxycarbonyltropane
- AD-1211
- AH-7921
- Axomadol
- Azaprocin
- BDPC
- Bisnortilidine [51] [52]
- BRL-52537
- Bromadol
- Bromadoline
- Ciprefadol
- Ciramadol
- Doxpicomine
- Enadoline
- Faxeladol
- GR-89696
- Herkinorin
- ICI-199,441
- ICI-204,448
- Ketamine
- KNT-42
- LPK-26
- Lufuradom
- Metofoline
- MT-45
- Desmethylclozapine
- Nexeridine
- NNC 63-0532
- Nortilidine
- O-Desmethyltramadol
- Phenadone
- Phencyclidine
- Prodilidine
- Profadol
- Ro64-6198
- Salvinorin A
- Salvinorin B ethoxymethyl ether
- Salvinorin B methoxymethyl ether
- SB-612,111
- SC-17599
- RWJ-394,674
- TAN-67
- Tapentadol
- Thiobromadol (C-8813)
- Tifluadom
- Tilidine
- Tramadol
- Trimebutine
- U-47700
- U-50,488
- U-69,593
- Viminol
- 1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide (W-18)
Opioid antagonists and inverse agonists
- 4-Caffeoyl-1,5-quinide
- 5'-Guanidinonaltrindole
- β-Funaltrexamine
- 6β-Naltrexol
- 6β-Naltrexol-d4
- Alvimopan
- AT-076
- Binaltorphimine
- BU09059
- Buprenorphine
- Chlornaltrexamine
- Clocinnamox
- Cyclazocine
- Cyprodime
- Diacetylnalorphine [53]
- Diprenorphine (M5050)
- Fedotozine
- ICI-174864
- J-113,397
- JDTic
- JTC-801
- Levallorphan
- LY-2456302
- LY-255582
- Methocinnamox
- Methylnaltrexone
- ML350
- Naldemedine
- Nalfurafine
- Nalmefene
- Nalmexone [54]
- Nalodeine (N-allylnorcodeine) [55]
- Naloxazone
- Naloxegol
- Naloxol
- Naloxonazine
- Naloxone
- Naloxone benzoylhydrazone
- Nalorphine
- Naltrexone
- Naltriben
- Naltrindole
- Norbinaltorphimine
- Oxilorphan
- PF-4455242
- S-allyl-3-hydroxy-17-thioniamorphinan (SAHTM)[56]
- Samidorphan
- SR-16430
Biased ligands
- 6'-Guanidinonaltrindole
- 7-Hydroxymitragynine
- Herkinorin
- ICI-199,441
- Noribogaine
- Oliceridine
- RB-64
- TRV734
Receptor heteromer targeting ligands
Uncategorized opioids
- ADL-5859
- Alimadol
- Amentoflavone
- Anilopam +HCl
- Asimadoline
- Cyproterone acetate
- FE 200665
- Fedotozine
- HZ-2
- Kolokol-1
- Matrine
- MCOPPB
- Menthol
- MT-7716
- Nalfurafine
- Nalorphine
- Nalorphine dinicotinate
- PZM21
- Proglumide
- Ro65-6570
- SoRI-9409
- Spiradoline
- SR-8993
- SR-16435
Structures
Uncategorized opioids | ||||
---|---|---|---|---|
FE 200665 |
||||
Nalodeine | ||||
Combination drug formulations containing opioids
- Buprenorphine/naloxone
- Buprenorphine/samidorphan (ALKS-5461)
- Co-codamol (codeine phosphate/paracetamol)
- Co-codaprin (codeine phosphate/aspirin)
- Co-dydramol (dihydrocodeine tartrate/paracetamol)
- Co-proxamol (dextropropoxyphene/paracetamol)
- Fentanyl/fluanisone
- Hydrocodone/ibuprofen
- Hydrocodone/paracetamol
- Loperamide/simethicone
- Morphine/naltrexone
- Naltrexone/bupropion
- Oxycodone/aspirin
- Oxycodone/naloxone
- Oxycodone/paracetamol
See also
- List of opioids by visual 2D molecular skeletal renderings (bundled remotely, click "show" after following link)
- List of Schedule I drugs (US)
- Gray death
References
- ↑ ChemIndex CAS Registry Number 3371-56-0
- ↑ ChemIndex CAS Registry Number 509-56-8
- ↑ ChemIndex CAS Registry Number 63715-94-6
- ↑ NCBI PubChem SID 750205
- ↑ chembase [yes|permanent dead link|dead link}}] cbid_346222
- ↑ "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proc. Natl. Acad. Sci. U.S.A. 110 (29): 12072–7. 2013. doi:10.1073/pnas.1222044110. PMID 23818586. Bibcode: 2013PNAS..11012072G.
- ↑ "N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers". Proc. Natl. Acad. Sci. U.S.A. 108 (12): 5098–103. 2011. doi:10.1073/pnas.1016277108. PMID 21385944. Bibcode: 2011PNAS..108.5098Y.
External links
- Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time." Russian Chemical Bulletin. August 2008, Volume 57, Issue 8, pp 1773–1774. Date: 11 Aug 2009; I. V. Evsikova, S. K. Moiseev, P. V. Petrovskii, V. N. Kalinin. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1739–1740
Original source: https://en.wikipedia.org/wiki/List of opioids.
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