Chemistry:List of opioids

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Opium poppy (Papaver somniferum) flower

This is a list of opioids, opioid antagonists and inverse agonists.

Opium and poppy straw derivatives

Seedhead of opium poppy with white latex

Crude opiate extracts whole opium products


Natural opiates

Opium alkaloids

Structures
Morphides
Chemical structure of codeine. Codeine Chemical structure of morphine. Morphine Chemical structure of oripavine. Oripavine Chemical structure of pseudomorphine. Pseudomorphine Chemical structure of thebaine. Thebaine


Alkaloid salts mixtures

  • Pantopon
  • Papaveretum (Omnopon)
  • Tetrapon


Semisynthetics including Bentley compounds

Morphine family

Structures of Morphine family
Morphine family
Chemical structure of 14-hydroxymorphine.14-Hydroxymorphine Chemical structure of 2,4-dinitrophenylmorphine.2,4-Dinitrophenylmorphine Chemical structure of 6-methyldihydromorphine.6-Methyldihydromorphine Chemical structure of 6-methylenedihydrodesoxymorphine.6-Methylenedihydrodesoxymorphine Chemical structure of 6-acetyldihydromorphine hydrochloride.6-Acetyldihydromorphine hydrochloride
Chemical structure of azidomorphine. Azidomorphine Chemical structure of chlornaltrexamine. Chlornaltrexamine Chemical structure of chloroxymorphamine. Chloroxymorphamine Chemical structure of desomorphine.Desomorphine
(Dihydrodesoxymorphine)
Chemical structure of dihydromorphine. Dihydromorphine
Chemical structure of ethyldihydromorphine. Ethyldihydromorphine Chemical structure of hydromorphinol. Hydromorphinol Chemical structure of methyldesorphine. Methyldesorphine Chemical structure of N-phenethylnormorphine. N-Phenethylnormorphine Chemical structure of 6-nicotinoyldihydromorphine.6-nicotinoyldihydromorphine
Chemical structure of RAM-378. RAM-378

3,6-diesters of morphine

Structures
3,6-diesters of morphine
Chemical structure of acetylpropionylmorphine. Acetylpropionylmorphine 3,6-Dibutanoylmorphine Chemical structure of diacetyldihydromorphine.Diacetyldihydromorphine
(dihydroheroin, acetylmorphinol)
Chemical structure of dibutyrylmorphine. Dibutyrylmorphine Chemical structure of dibenzoylmorphine. Dibenzoylmorphine Chemical structure of diformylmorphine. Diformylmorphine
Chemical structure of dipropanoylmorphine. Dipropanoylmorphine Chemical structure of heroin.Heroin
(diacetylmorphine)
Chemical structure of nicomorphine. Nicomorphine


Codeine-dionine family


Structures

Morphinones and morphols


Morphides


Structures
Morphides
Chemical structure of alpha-chlorocodide. α-chlorocodide Chemical structure of beta-chlorocodide. β-chlorocodide Chemical structure of bromomorphide. Bromomorphide
Chemical structure of chlorodihydrocodide. Chlorodihydrocodide. Chemical structure of chloromorphide. Chloromorphide Chemical structure of codide. Codide

Dihydrocodeine series


Nitrogen morphine derivatives

Structures
Morphides
Chemical structure of 1-nitrocodeine. 1-Nitrocodeine Chemical structure of codeine-N-oxide. Codeine-N-oxide Chemical structure of morphine-N-oxide. Morphine-N-oxide

Hydrazones

Structures
Hydrazones
Chemical structure of oxymorphazone. Oxymorphazone

Halogenated morphine derivatives

Structures
Other open chain opioids
Chemical structure of 1-bromocodeine.

1-Bromocodeine

Chemical structure of 1-chlorocodeine.

1-Chlorocodeine

General structure of 1-iodomorphine.

1-Iodomorphine

Active opiate metabolites


Structures

Morphinans

Levomethorphan

Morphinan series

Structures
Other morphinans
Chemical structure of 4-chlorophenylpyridomorphinan 4-chlorophenylpyridomorphinan Chemical structure of cyclorphan. Cyclorphan Chemical structure of dextrallorphan. Dextrallorphan Chemical structure of levargorphan Levargorphan Chemical structure of levophenacylmorphan. Levophenacylmorphan
Chemical structure of levomethorphan Levomethorphan Chemical structure of norlevorphanol. Norlevorphanol Chemical structure of N-methylmorphinan. N-Methylmorphinan Chemical structure of oxilorphan. Oxilorphan Chemical structure of phenomorphan. Phenomorphan
Chemical structure of dextromethorphan. Dextromethorphan 70 px|Chemical structure of Levomethorphan. levomethorphan Chemical structure of morphanol. Morphanol Chemical structure of Ro4-1539. Ro4-1539 Chemical structure of stephodeline. Stephodeline Chemical structure of xorphanol. Xorphanol

Others

Structures
Other Morphinans
Chemical structure of 1-nitroaknadinine 1-Nitroaknadinine Chemical structure of 14-episinomenine. 14-episinomenine Chemical structure of 5,6-dihydronorsalutaridine. 5,6-Dihydronorsalutaridine Chemical structure of 6-keto-nalbuphine 6-Keto Nalbuphine Chemical structure of aknadinine. Aknadinine
Chemical structure of butorphanol Butorphanol Chemical structure of cephakicine. Cephakicine Chemical structure of cephasamine. Cephasamine Chemical structure of cyprodime. Cyprodime Chemical structure of drotebanol. Drotebanol
Chemical structure of fenfangjine G. Fenfangjine G Chemical structure of nalbuphine. Nalbuphine Chemical structure of sinococuline. Sinococuline Chemical structure of sinomenine. Sinomenine Chemical structure of tannagine. Tannagine

Benzomorphans

[36]-->

4-Phenylpiperidines

Pethidine

Pethidines (meperidines)


Prodines


Ketobemidones


Others


Structures
Other phenylpiperidines
Chemical structure of alvimopan.Alvimopan Chemical structure of loperamide. Loperamide Chemical structure of LS-115509. LS-115509 General structure of picenadol. Picenadol

Open chain opioids

Methadone

Amidones


Methadols


Structures
Other open chain opioids
Chemical structure of alphaacetylmethadol.

Alphaacetylmethadol

Chemical structure of fimepheptanol.

Dimepheptanol

General structure of levacetylmethadol.

Levacetylmethadol

Chemical structure of noracetylmethadol.

Noracetylmethadol

Moramides


Thiambutenes


Phenalkoxams


Ampromides


Structures

Others


Structures
Other open chain opioids
Chemical structure of embutramide.

Embutramide

Chemical structure of IC-26.

IC-26

Chemical structure of isoaminile.

Isoaminile

General structure of lefetamine.

Lefetamine

Chemical structure of R-4066.

R-4066

Anilidopiperidines

Fentanyl


Oripavine derivatives

Thienorphine


Phenazepanes


Pirinitramides


Structures
Pirinitramides
Chemical structure of bezitramide.

Bezitramide

Chemical structure of piritramide.

Piritramide

Benzimidazoles


Structures

Indoles


Beta-Amino Ketones

  • 3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one


Structures
Indoles
Chemical structure of beta-amine ketone 'compound 29'

3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one (Beta-amine ketone 'compound 29')

Diphenylmethylpiperazines


Structures
Diphenylmethylpiperazines
Chemical structure of BW373U86.

BW373U86

Chemical structure of DPI-221.

DPI-221

Chemical structure of DPI-287.

DPI-287

Chemical structure of DPI-3290.

DPI-3290

Chemical structure of SNC-80.

SNC-80

Opioid peptides

β-neoendorphin

Dynorphins


Structures

Endomorphins


Endorphins


Structures
Dynorphins
Chemical structure of beta-endorphin. Beta-endorphin Chemical structure of alpha-endorphin. Alpha-endorphin Chemical structure of gamma-endorphin. Gamma-endorphin Chemical structure of α-neo-endorphin. α-neoendorphin Chemical structure of β-neo-endorphin. β-neoendorphin

Enkephalins


Propeptides


Others / unknown


Structures
Other or unknown opioid peptides
Chemical structure of adrenorphin. Adrenorphin Chemical structure of amidorphin. Amidorphin Chemical structure of casomorphin. Casomorphin Chemical structure of DALDA. DALDA Chemical structure of deltorphin. Deltorphin
Chemical structure of dermorphin. Dermorphin Chemical structure of DPDPE. DPDPE Chemical structure of Endomorphin-1. Endomorphin-1
135 px|Chemical structure of Endomorphin-2. Endomorphin-2
Chemical structure of gliadorphin. Gliadorphin Chemical structure of morphiceptin. Morphiceptin
Chemical structure of nociceptin. Nociceptin Chemical structure of octreotide. Octreotide Chemical structure of opiorphin. Opiorphin Chemical structure of rubiscolin. Rubiscolin Chemical structure of TRIMU 5. TRIMU 5

Others


Opioid antagonists and inverse agonists


Biased ligands


Receptor heteromer targeting ligands


Uncategorized opioids


Combination drug formulations containing opioids

  • Buprenorphine/naloxone
  • Buprenorphine/samidorphan (ALKS-5461)
  • Co-codamol (codeine phosphate/paracetamol)
  • Co-codaprin (codeine phosphate/aspirin)
  • Co-dydramol (dihydrocodeine tartrate/paracetamol)
  • Co-proxamol (dextropropoxyphene/paracetamol)
  • Fentanyl/fluanisone
  • Hydrocodone/ibuprofen
  • Hydrocodone/paracetamol
  • Loperamide/simethicone
  • Morphine/naltrexone
  • Naltrexone/bupropion
  • Oxycodone/aspirin
  • Oxycodone/naloxone
  • Oxycodone/paracetamol


See also

References

External links

  • Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time." Russian Chemical Bulletin. August 2008, Volume 57, Issue 8, pp 1773–1774. Date: 11 Aug 2009; I. V. Evsikova, S. K. Moiseev, P. V. Petrovskii, V. N. Kalinin. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1739–1740