Chemistry:BRL-52537
From HandWiki
Short description: Chemical compound
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| Formula | C18H24Cl2N2O |
| Molar mass | 355.30 g·mol−1 |
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BRL-52537 is a drug which acts as a potent and highly selective κ-opioid agonist.[1] It has neuroprotective effects in animal studies,[2][3] and is used for research into potential treatments for stroke and heart attack as well as more general brain research.[4][5][6]
References
- ↑ "(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics". Journal of Medicinal Chemistry 34 (1): 397–403. January 1991. doi:10.1021/jm00105a061. PMID 1846921.
- ↑ "Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats". Stroke: A Journal of Cerebral Circulation 34 (6): 1533–8. June 2003. doi:10.1161/01.STR.0000072512.30658.E7. PMID 12738895.
- ↑ "Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats". Anesthesia and Analgesia 97 (6): 1776–83. December 2003. doi:10.1213/01.ane.0000087800.56290.2e. PMID 14633559.
- ↑ "Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats". Stroke: A Journal of Cerebral Circulation 35 (5): 1180–5. May 2004. doi:10.1161/01.STR.0000125011.93188.c6. PMID 15031456.
- ↑ "Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction". Journal of Cardiovascular Pharmacology 43 (3): 410–5. March 2004. doi:10.1097/00005344-200403000-00012. PMID 15076225.
- ↑ "Presynaptic opioid and nicotinic receptor modulation of dopamine overflow in the nucleus accumbens". Journal of Neuroscience 28 (7): 1672–81. February 2008. doi:10.1523/JNEUROSCI.4275-07.2008. PMID 18272687.
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