Chemistry:SoRI-9409
From HandWiki
Short description: Chemical compound
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| Formula | C29H27ClN2O3 |
| Molar mass | 487.00 g·mol−1 |
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SoRI-9409 is a mixed mu opioid receptor partial agonist and delta opioid receptor antagonist, used in biomedical research. It produces moderate analgesic effects without development of tolerance and with reduced withdrawal symptoms compared to standard opioid analgesics,[1] as well as showing anti-addictive effects that may be useful in the treatment of alcoholism.[2][3]
References
- ↑ "In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence". The Journal of Pharmacology and Experimental Therapeutics 297 (2): 597–605. May 2001. PMID 11303048.
- ↑ "A novel delta opioid receptor antagonist, SoRI-9409, produces a selective and long-lasting decrease in ethanol consumption in heavy-drinking rats". Biological Psychiatry 64 (11): 974–81. December 2008. doi:10.1016/j.biopsych.2008.07.018. PMID 18774553.
- ↑ "The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking". Addiction Biology 17 (2): 224–34. March 2012. doi:10.1111/j.1369-1600.2010.00295.x. PMID 21309957.
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