Chemistry:Bevenopran

Short description: Chemical compound

Bevenopran

Legal status
Legal status	Investigational
Identifiers
IUPAC name 5-[2-Methoxy-4-[[2-(oxan-4-yl)ethylamino]methyl]phenoxy]pyrazine-2-carboxamide
CAS Number	676500-67-7
PubChem CID	10452732
ChemSpider	8628148
UNII	IC58Q2EHPJ
KEGG	D10349
Chemical and physical data
Formula	C20H26N4O4
Molar mass	386.452 g·mol−1
3D model (JSmol)	Interactive image
SMILES COC1=C(C=CC(=C1)CNCCC2CCOCC2)OC3=NC=C(N=C3)C(=O)N
InChI InChI=1S/C20H26N4O4/c1-26-18-10-15(11-22-7-4-14-5-8-27-9-6-14)2-3-17(18)28-19-13-23-16(12-24-19)20(21)25/h2-3,10,12-14,22H,4-9,11H2,1H3,(H2,21,25) Key:ZGCYVRNZWGUXNQ-UHFFFAOYSA-N

Bevenopran (INN, USAN) (former developmental code names CB-5945, ADL-5945, MK-2402, OpRA III) is a peripherally acting μ-opioid receptor antagonist that also acts on δ-opioid receptors and was under development by Cubist Pharmaceuticals for the treatment of chronic opioid-induced constipation. It reached phase III clinical trials for this indication before being discontinued.

See also

• Alvimopan
• Axelopran
• Eluxadoline
• Methylnaltrexone
• Naldemedine
• Naloxegol