Chemistry:Phescaline
Phescaline (PH), also known as 4-phenoxy-3,5-dimethoxyphenethylamine, is a chemical compound of the phenethylamine and scaline families related to the psychedelic drug mescaline.[1] It is the derivative of mescaline in which the methoxy group at the 4 position has been replaced with a phenoxy group.[1]
According to Daniel Trachsel and colleagues in their book Phenethylamine: von der Struktur zur Funktion, phescaline is not known to have been synthesized, studied, or tested in humans.[1] However, analogues of phescaline like benzscaline (BZ) and 3C-BZ are known to be potent serotonin 5-HT2A receptor agonists and/or psychedelics, and phescaline may be active as a psychedelic similarly.[1][2][3] On the other hand, the longer-chain analogue phenescaline was found to have little activity in humans at tested doses.[1][3]
Phescaline was first described in the literature by Trachsel and colleagues in Phenethylamine: von der Struktur zur Funktion in 2013.[1]
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 (in de) Phenethylamine: von der Struktur zur Funktion. Nachtschatten-Science (1 ed.). Solothurn: Nachtschatten-Verlag. 2013. ISBN 978-3-03788-700-4. OCLC 858805226. https://books.google.com/books?id=-Us1kgEACAAJ.
- ↑ "Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines". Frontiers in Pharmacology 12. 2021. doi:10.3389/fphar.2021.794254. PMID 35222010.
- ↑ 3.0 3.1 Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. http://www.erowid.org/library/books_online/pihkal/pihkal.shtml.
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