Chemistry:Rosolutamide

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Rosolutamide (INN; developmental code name ASC-JM17, JM17, ALZ-003) is an agonist of nuclear respiratory factor 1 (NRF1), a nonsteroidal antiandrogen, and an androgen receptor degrader related to curcumin.[1][2][3][4][5] Other analogues like dimethylcurcumin (ASC-J9) are also known.[2][6]

See also

References

  1. ↑ "Proposed INN: List 131 International Nonproprietary Names for Pharmaceutical Substances (INN)". WHO Drug Information 38 (2): 428. 2024. https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl131.pdf#page=194. 
  2. ↑ 2.0 2.1 "The Role of NRF2 in Trinucleotide Repeat Expansion Disorders". Antioxidants 13 (6): 649. May 2024. doi:10.3390/antiox13060649. PMID 38929088. 
  3. ↑ "Nrf1 is paved as a new strategic avenue to prevent and treat cancer, neurodegenerative and other diseases". Toxicology and Applied Pharmacology 360: 273–283. December 2018. doi:10.1016/j.taap.2018.09.037. PMID 30267745. Bibcode: 2018ToxAP.360..273Y. 
  4. ↑ "A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy". Human Molecular Genetics 25 (10): 1979–1989. May 2016. doi:10.1093/hmg/ddw073. PMID 26962150. 
  5. ↑ "In Vitro Efficacy and Molecular Mechanism of Curcumin Analog in Pathological Regulation of Spinocerebellar Ataxia Type 3". Antioxidants 11 (7): 1389. July 2022. doi:10.3390/antiox11071389. PMID 35883884. 
  6. ↑ "Therapeutic targeting of the polyglutamine androgen receptor in Spinal and Bulbar Muscular Atrophy". Expert Opinion on Therapeutic Targets: 1–13. February 2025. doi:10.1080/14728222.2025.2464173. PMID 39915972. 



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