Chemistry:Naltriben
From HandWiki
Short description: Chemical compound
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| Formula | C26H25NO4 |
| Molar mass | 415.489 g·mol−1 |
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Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.[1] It also acts as a κ-opioid agonist at high doses.[2]
See also
References
- ↑ "Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes". The Journal of Pharmacology and Experimental Therapeutics 257 (2): 676–80. May 1991. PMID 1851833.
- ↑ "Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes". Life Sciences 55 (4): PL79-84. 1994. doi:10.1016/0024-3205(94)00738-1. PMID 8028443.
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