Chemistry:ICI-204,448
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Short description: Chemical compound
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| Formula | C23H26Cl2N2O4 |
| Molar mass | 465.37 g·mol−1 |
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ICI-204,448 is a drug which acts as a potent and peripherally selective κ-opioid agonist, with possible uses in the treatment of heart attack as well as anti-itching effects.[1][2] It is used in research to distinguish centrally from peripherally mediated kappa opioid receptor effects.[3][4]
References
- ↑ "Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction". Journal of Cardiovascular Pharmacology 43 (3): 410–5. March 2004. doi:10.1097/00005344-200403000-00012. PMID 15076225.
- ↑ "Kappa opioid agonists suppress chloroquine-induced scratching in mice". European Journal of Pharmacology 502 (3): 233–7. October 2004. doi:10.1016/j.ejphar.2004.09.010. PMID 15476749.
- ↑ "Effects of kappa opioid agonists alone and in combination with cocaine on heart rate and blood pressure in conscious squirrel monkeys". European Journal of Pharmacology 576 (1–3): 107–13. December 2007. doi:10.1016/j.ejphar.2007.07.053. PMID 17707792.
- ↑ "Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats". Neuropharmacology 53 (8): 930–41. December 2007. doi:10.1016/j.neuropharm.2007.09.002. PMID 17959202.
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