Chemistry:4-Thiotrisescaline
4-Thiotrisescaline (4-T-TRIS), also known as 4-thiotrescaline or as 4-ethylthio-3,5-diethoxyphenethylamine, is a chemical compound of the phenethylamine and scaline families related to mescaline.[1][2][3][4] It is the analogue of trisescaline (TRIS; trescaline) in which the ethoxy group at the 4 position has been replaced with an ethylthio group.[1][2][3][4] The drug is one of two possible thiotrisescaline (T-TRIS; thiotrescaline) positional isomers, the other being 3-thiotrisescaline (3-T-TRIS; 3-thiotrescaline).[1][2][3][4]
In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 4-T-TRIS's dose as greater than 200 mg orally and its duration as unknown.[1][2][3] The effects of 4-T-TRIS have been reported to include possibly some physical effects, slight tingling or numbing of hands and fingers, gas, and no mental effects at a dose of 120 mg orally in one report.[1] However, in another report in which a higher dose of 200 mg orally was used, there were, aside from a brief passing awareness, no physical or mental effects whatsoever.[1] Shulgin concluded that the compound is inactive.[1]
The chemical synthesis of 4-T-TRIS has been described.[1][4]
4-T-TRIS was first described in the scientific literature by Shulgin and Peyton Jacob III in 1984.[4] Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.[1]
See also
- Scaline
- 3-Thiotrisescaline
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. http://www.erowid.org/library/books_online/pihkal/pihkal.shtml. https://www.erowid.org/library/books_online/pihkal/pihkal179.shtml
- ↑ 2.0 2.1 2.2 2.3 "Structure-Activity Relationships of the Classic Hallucinogens and Their Analogs". Hallucinogens: An Update. National Institute on Drug Abuse Research Monograph Series. 146. National Institute on Drug Abuse. 1994. pp. 74–91. https://bibliography.maps.org/resources/download/11534.
- ↑ 3.0 3.1 3.2 3.3 "Basic Pharmacology and Effects". Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. 2003. pp. 67–137. ISBN 978-0-12-433951-4. https://bibliography.maps.org/resources/download/12634.
- ↑ 4.0 4.1 4.2 4.3 4.4 "Sulfur analogues of psychotomimetic agents. 3. Ethyl homologues of mescaline and their monothio analogues". J Med Chem 27 (7): 881–888. July 1984. doi:10.1021/jm00373a013. PMID 6737431.
External links
- 4-T-TRIS (4-Thiotrisescaline) - Isomer Design
- 4-T-TRIS (4-Thiotrisescaline) - PiHKAL - Erowid
- 4-T-TRIS (4-Thiotrisescaline) - PiHKAL - Isomer Design
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