Chemistry:GSK2881078
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Short description: Chemical compound
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| Formula | C14H13F3N2O2S |
| Molar mass | 330.33 g·mol−1 |
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GSK2881078 is a drug which acts as a selective androgen receptor modulator (SARM). It was developed for the prevention of muscle wasting and sarcopenia in elderly people.[1][2][3]
In a phase II trial the drug was shown to be well tolerated and increased muscle strength in men with COPD.[4]
See also
References
- ↑ "Safety, pharmacokinetics and pharmacological effects of the selective androgen receptor modulator, GSK2881078, in healthy men and postmenopausal women". British Journal of Clinical Pharmacology 83 (10): 2179–2194. October 2017. doi:10.1111/bcp.13316. PMID 28449232.
- ↑ "GSK2881078, a SARM, Produces Dose-Dependent Increases in Lean Mass in Healthy Older Men and Women". The Journal of Clinical Endocrinology and Metabolism 103 (9): 3215–3224. September 2018. doi:10.1210/jc.2017-02644. PMID 29982690.
- ↑ "Comparison of the three SARMs RAD-140, GLPG0492 and GSK-2881078 in two different in vitro bioassays, and in an in silico androgen receptor binding assay". The Journal of Steroid Biochemistry and Molecular Biology 189: 81–86. May 2019. doi:10.1016/j.jsbmb.2019.02.014. PMID 30825507.
- ↑ "Selective androgen receptor modulation for muscle weakness in chronic obstructive pulmonary disease: a randomised control trial". Thorax 78 (3): 258–266. March 2023. doi:10.1136/thorax-2021-218360. PMID 36283827.
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