Chemistry:JNJ-20788560
From HandWiki
JNJ-20788560 is a potent opioid drug selective for the delta opioid receptor.[1]
Mechanism of action
It works by activating opioid receptors, but it is selective for the δ-opioid receptor. This selectivity allows this drug to have less side effects than opioids such as morphine.
Tests have revealed that JNJ-20788560 does not produce hypoventilation, tolerance, or physical dependence.[2]
References
- ↑ Codd, Ellen E.; Ma, Jianya; Zhang, Sui-Po; Stone, Dennis J.; Colburn, Raymond W.; Brandt, Michael R.; Chevalier, Kristen M.; Zhu, Yongxin et al. (August 2010). "Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range". Pharmacology, Biochemistry, and Behavior 96 (2): 130–135. doi:10.1016/j.pbb.2010.04.020. ISSN 1873-5177. PMID 20438745.
- ↑ Codd, Ellen E.; Carson, John R.; Colburn, Raymond W.; Stone, Dennis J.; Van Besien, Christopher R.; Zhang, Sui-Po; Wade, Paul R.; Gallantine, Elizabeth L. et al. (April 2009). "JNJ-20788560 [9-(8-azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide], a selective delta opioid receptor agonist, is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic tolerance, or physical dependence". The Journal of Pharmacology and Experimental Therapeutics 329 (1): 241–251. doi:10.1124/jpet.108.146969. ISSN 1521-0103. PMID 19151246.
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