Chemistry:MGM-15
From HandWiki
MGM-15 is an opioid drug which is a semi-synthetic derivative of 7-hydroxymitragynine, a natural product derived from the South-East Asian tree kratom. MGM-15 was first reported in 2014. It is the 1,2-dihydro derivative of 7-hydroxymitragynine and shows higher potency as an agonist of the mu opioid receptor and delta opioid receptor compared to 7-hydroxymitragynine itself. MGM-15 has been sold as a designer drug since early 2025, initially in the USA. The 9-fluoro derivative of MGM-15 is known as MGM-16, and has even higher potency as an opioid agonist with around 240x the potency of morphine in animal studies.[1][2][3][4][5][6]
See also
References
- ↑ "Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice". The Journal of Pharmacology and Experimental Therapeutics 348 (3): 383–392. March 2014. doi:10.1124/jpet.113.208108. PMID 24345467.
- ↑ Kratom and Other Mitragynines. 2014. doi:10.1201/b17666. ISBN 978-1-4822-2519-8.
- ↑ "A Review on the Antinociceptive Effects of Mitragyna speciosa and Its Derivatives on Animal Model". Current Drug Targets 19 (12): 1359–1365. 2018. doi:10.2174/1389450118666170925154025. PMID 28950813.
- ↑ "Site selective C-H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy". Nature Communications 12 (1). June 2021. doi:10.1038/s41467-021-23736-2. PMID 34158473. Bibcode: 2021NatCo..12.3858B.
- ↑ "Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources". Journal of Medicinal Chemistry 65 (3): 1612–1661. February 2022. doi:10.1021/acs.jmedchem.0c01915. PMID 34995453.
- ↑ "From Kratom to Semi-Synthetic Opioids: The Rise and Risks of MGM-15". Drug Testing and Analysis. September 2025. doi:10.1002/dta.3952. PMID 40936282.
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