Chemistry:Mofegiline
From HandWiki
Short description: Chemical compound
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| Other names | MDL-72,974A |
| Routes of administration | Oral[1] |
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| Elimination half-life | 1–3 hours[1] |
| Excretion | Urine[2] |
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| Formula | C11H13F2N |
| Molar mass | 197.229 g·mol−1 |
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Mofegiline (MDL-72,974) is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) which was under investigation for the treatment of Parkinson's disease and Alzheimer's disease,[3][4][5][6] but was never marketed.[7]
See also
References
- ↑ 1.0 1.1 "Pharmacokinetics and pharmacodynamics of the monoamine oxidase B inhibitor mofegiline assessed during a phase I dose tolerance trial". Clinical Pharmacology and Therapeutics 58 (3): 342–53. September 1995. doi:10.1016/0009-9236(95)90252-X. PMID 7554709.
- ↑ "Pharmacokinetics of and monoamine oxidase B inhibition by (E)-4-fluoro-beta-fluoromethylene benzene butanamine in man". Arzneimittel-Forschung 43 (3): 297–302. March 1993. PMID 8489556.
- ↑ "Design and early clinical evaluation of selective inhibitors of monoamine oxidase". Progress in Neuro-psychopharmacology & Biological Psychiatry 12 (6): 967–87. 1988. doi:10.1016/0278-5846(88)90092-9. PMID 3266532.
- ↑ "MDL 72,974: a potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potential for use in Parkinson's disease". Journal of Neural Transmission. Parkinson's Disease and Dementia Section 1 (4): 243–54. 1989. doi:10.1007/bf02263478. PMID 2597310.
- ↑ "Haloallylamine inhibitors of MAO and SSAO and their therapeutic potential". Amine Oxidases: Function and Dysfunction. 41. 1994. 407–14. doi:10.1007/978-3-7091-9324-2_54. ISBN 978-3-211-82521-1.
- ↑ "Effect of the MAO-B inhibitor, MDL72974, on superoxide dismutase activity and lipid peroxidation levels in the mouse brain". Synapse 28 (3): 208–11. March 1998. doi:10.1002/(SICI)1098-2396(199803)28:3<208::AID-SYN3>3.0.CO;2-E. PMID 9488505.
- ↑ Dictionary of pharmacological agents. CRC Press. 1997. p. 1370. ISBN 978-0-412-46630-4. https://books.google.com/books?id=A0THacd46ZsC&pg=PA1370. Retrieved 25 November 2011.
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