Chemistry:Etanautine

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Short description: Chemical compound

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Etanautine
Etanautine.svg
Clinical data
ATC code
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UNII
Chemical and physical data
FormulaC26H31N5O5
Molar mass493.564 g·mol−1
3D model (JSmol)
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Etanautine, also known as diphenhydramine monoacefyllinate, is an anticholinergic used as an antiparkinsonian agent. It is a 1:1 salt of diphenhydramine with acefylline, similar to the diphenhydramine/8-chlorotheophylline combination product dimenhydrinate.[1]

As with dimenhydrinate, the stimulant effect of the etanautine counteracts the sedative effect from the diphenhydramine, resulting in an improved therapeutic profile.[2]

The 1:2 salt diphenhydramine diacefylline (with two molecules of acefylline to each molecule of diphenhydramine) is also used in medicine, under the brand name Nautamine.[1][3]

References

  1. 1.0 1.1 "Diphenhydramine". StatPearls. Treasure Island (FL): StatPearls Publishing. 2022. http://www.ncbi.nlm.nih.gov/books/NBK526010/. Retrieved 2022-11-02. 
  2. "Diphenhydramine may be useful as a palliative treatment for patients dying with Parkinson's disease and tremors: a case report and discussion". The American Journal of Hospice & Palliative Care 26 (6): 474–475. August 21, 2009. doi:10.1177/1049909109338937. PMID 19700649. 
  3. "Diphenhydramine Dosage Guide + Max Dose, Adjustments" (in en). https://www.drugs.com/dosage/diphenhydramine.html.