Chemistry:N-Acetylmescaline
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| Formula | C13H19NO4 |
| Molar mass | 253.298 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 93 to 94 °C (199 to 201 °F) |
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N-Acetylmescaline is a mescaline derivative found in trace quantities in peyote (Lophophora williamsii).[1] It is a metabolite of mescaline in humans, but it has little pharmacological activity of its own.[2] At doses of up to 750 mg, only mild drowsiness was observed.[2][3] Hence, N-acetylmescaline appears to be inactive as a hallucinogen.[3] N-Acetylmescaline has microtubule assembly inhibitory activity.[4]
See also
- Substituted methoxyphenethylamine
- Scaline
- N-Formylmescaline
- N,N-Diformylmescaline
References
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs namedBuckingham - ↑ 2.0 2.1 "Psychotomimetic Agents". Psychopharmacological Agents. 4. Academic Press. 1976. pp. 94. ISBN 978-0-323-15963-0.
- ↑ 3.0 3.1 Mangner TJ (1978). Potential Psychotomimetic Antagonists. N,n -diethyl-1-methyl-3-aryl-1, 2, 5, 6-tetrahydropyridine-5-carboxamides (Ph.D. thesis). University of Michigan. doi:10.7302/11268. Archived from the original on 30 March 2025.
Two N-substituted mescaline analogs isolated from L. williamsii are N-methylmescaline (62a) and N-acetylmescaline (62b).95 N-Methylmescaline shows no central effects at a dose which would represent many times the level that would be encountered in a normal dose of peyote.67 N-Acetylmescaline, which has been identified as a metabolite of mescaline in man, is centrally inactive to 750 mg.96
- ↑ "The mechanism of tubulin-colchicine recognition--a kinetic study of the binding of a bicyclic colchicine analogue with a minor modification of the A ring". European Journal of Biochemistry 249 (1): 265–269. October 1997. doi:10.1111/j.1432-1033.1997.t01-1-00265.x. PMID 9363778.
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