Chemistry:O-Phenyl-3-iodotyramine
From HandWiki
Short description: Chemical compound
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| Formula | C14H14INO |
| Molar mass | 339.176 g·mol−1 |
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o-Phenyl-3-iodotyramine (o-PIT) is a drug which acts as a selective agonist for the trace amine-associated receptor 1. It has reasonable selectivity for TAAR1 but relatively low potency, and is rapidly metabolised in vivo, making it less useful for research than newer ligands such as RO5166017.[1][2][3][4]
References
- ↑ "Trace amine-associated receptors and their ligands". British Journal of Pharmacology 149 (8): 967–78. December 2006. doi:10.1038/sj.bjp.0706948. PMID 17088868.
- ↑ "Trace amines depress D(2)-autoreceptor-mediated responses on midbrain dopaminergic cells". British Journal of Pharmacology 160 (6): 1509–20. July 2010. doi:10.1111/j.1476-5381.2010.00792.x. PMID 20590640.
- ↑ "TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity". Proceedings of the National Academy of Sciences of the United States of America 108 (20): 8485–90. May 2011. doi:10.1073/pnas.1103029108. PMID 21525407. Bibcode: 2011PNAS..108.8485R.
- ↑ "Genetic deletion of trace amine 1 receptors reveals their role in auto-inhibiting the actions of ecstasy (MDMA)". The Journal of Neuroscience 31 (47): 16928–40. November 2011. doi:10.1523/JNEUROSCI.2502-11.2011. PMID 22114263.
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