Chemistry:Trimeperidine
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| Other names | Trimeperidine, Promedol |
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| Formula | C17H25NO2 |
| Molar mass | 275.392 g·mol−1 |
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Trimeperidine (Promedol) is an opioid analgesic that is an analogue of prodine. It was developed in the early 1950s in the USSR during research into the related drug pethidine.[1]
Trimeperidine has four structural isomers, of which two are active, the γ isomer trimeperidine, and the β isomer isopromedol.[2][3] It is around half the potency of morphine as an analgesic,[4][5] and has been widely used for the treatment of pain.[6][7]
Trimeperidine produces similar effects to other opioids, such as analgesia and sedation, along with side effects such as nausea, itching, vomiting and respiratory depression which may be harmful or fatal.
Trimeperidine is in Schedule I of the Controlled Substances Act 1970 of the United States as a Narcotic with ACSCN 9646 with an annual aggregate manufacturing quota of 2 grams as of 2014. The free base conversion ratio for salts includes 0.883 for the hydrochloride. Promedol increases the activity of the reticular activating system in the brain.[8] It is listed under the Single Convention for the Control of Narcotic Substances 1961 and is controlled in most countries in the same fashion as is morphine or heroin.
References
- ↑ "Geterotsiklicheskie Soedineniya. 39. Sinteticheskie Obezbolivayushchie Veshchestva. 4. Slozhnye Efiry 1, 2, 5-Trimetil-4-Fenil-4-Piperidola S Alifaticheskimi Kislotami-Sintez Promedola I Izopromedola." (in ru). Zhurnal Obshchei Khimii 26 (10): 2798–811. January 1956. http://genchem.ru/.
- ↑ "Analgesic potency and stereochemistry of trimeperidine and its isomers and analogues". The Journal of Pharmacy and Pharmacology 23 (1): 68–9. January 1971. doi:10.1111/j.2042-7158.1971.tb12786.x. PMID 4395897.
- ↑ "Reversed ester analogues of pethidine: isomeric 4-acetoxy-1, 2, 6-trimethyl-4-phenylpiperidines". The Journal of Pharmacy and Pharmacology 28 (2): 106–10. February 1976. doi:10.1111/j.2042-7158.1976.tb04107.x. PMID 6668.
- ↑ "[Comparative analgesic effects of promedol, phenadone, tecodine, and morphine]" (in ru). Farmakologiia I Toksikologiia 19 (Suppl): 17–8. 1956. PMID 13448009.
- ↑ "[Relationship between the pain-relieving action of narcotic analgesics and their effect on respiration]" (in ru). Farmakologiia I Toksikologiia 39 (5): 552–6. 1976. PMID 18367.
- ↑ "[Anesthesia in labor]" (in ru). Fel'dsher I Akusherka 45 (6): 21–7. 1980. PMID 6901667.
- ↑ "[Method of continuous intravenous postoperative analgesia with promedol in newborn children]" (in ru). Anesteziologiia I Reanimatologiia (1): 12–6. 2004. PMID 15206301.
- ↑ "Quotas - 2014". Diversion Control Division. Drug Enforcement Agency, U.S. Department of Justice. http://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm.
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