Chemistry:LS-115509
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Short description: Chemical compound
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| Formula | C20H27NO2 |
| Molar mass | 313.441 g·mol−1 |
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LS-115509 is an opioid analgesic related to the 4-phenylpiperidine family. It is comparable to drugs such as prodine and pheneridine, but is distinguished by the presence of an ether group and furan ring at the piperidine 4-position, which are not found in other drugs of this class. In animal studies, it has around 2-3x the potency of morphine depending on what assay is used. Like prodine, it has two stereocenters and four possible enantiomers, but the activity of these has not been tested separately.[1][2][3]
See also
References
- ↑ "Chemistry and pharmacology of 4-alkoxy-piperidines related to reversed esters of pethidine". Journal of Medicinal and Pharmaceutical Chemistry 4 (3): 535–51. December 1961. doi:10.1021/jm50019a012. PMID 13877295.
- ↑ "Analgesics and their antagonists: biochemical aspects and structure-activity relationships". Progress in Medicinal Chemistry 4: 171–218. February 1965. doi:10.1016/s0079-6468(08)70169-3. ISBN 9780444533234. PMID 5319798.
- ↑ Opiates. Orlando: Academic Press. 1986. p. 337. ISBN 978-0-12-443830-9.
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