Chemistry:A1APU

From HandWiki

A1APU (10105-368-30-605-0) is a negative allosteric modulator (NAM) of the μ-opioid receptor (MOR) which has been developed as a potential treatment for opioid overdose. In animal studies it increases the potency and effective duration of naloxone making it able to block opioid-induced respiratory depression at a tenth of the normal dose.[1][2]

See also

  • MS1 (drug)

References

  1. ↑ "A µ-opioid receptor modulator that works cooperatively with naloxone". Nature 631 (8021): 686–693. July 2024. doi:10.1038/s41586-024-07587-7. PMID 38961287. Bibcode: 2024Natur.631..686O. 
  2. ↑ O'Brian E, Kumar KK, Kobilka B, "Allosteric Modulators of the μ-Opioid Receptor and Cannabinoid receptor 1", WO patent 2024/112721, published 2024-05-30, assigned to Cz Biohub Sf, Llcand The Board Of Trustees Of The Leland Stanford Junior University



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:A1APU&oldid=4032849"