Chemistry:AZD-7268
AZD-7268 is a δ-opioid receptor agonist which was under development for the treatment of major depressive disorder but was never marketed.[1][2][3] It is taken by mouth.[1]
The affinity (Ki) of AZD-7268 for the δ-opioid receptor was reported to be 2.7 nM and its selectivity for this receptor over the μ-opioid receptor was reported to be 2,000-fold.[4] No animal studies of AZD-7268 appear to have been published.[3][4] In addition to putative antidepressant effects, AZD-7268 might have anxiolytic effects.[4][3] Structurally, AZD-7268 was derived from SNC-80.[4]
Dose-limiting side effects of AZD-7268 in clinical trials included syncope (fainting), hypotension (low blood pressure), and dizziness.[3]
AZD-7268 was first described by 2007.[3] Its development was discontinued in 2010.[3][1] It reached phase 2 clinical trials prior to the discontinuation of its development.[1] No reason was given for the discontinuation of its development.[3] However, the drug was found to be ineffective for major depressive disorder in a phase 2 clinical trial of 231 participants comparing it with placebo and escitalopram.[3][5][4][6] The drug was under development by AstraZeneca.[1]
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 "AZD 7268". 5 November 2023. https://adisinsight.springer.com/drugs/800029682.
- ↑ "Delving into the Latest Updates on AZD-7268 with Synapse". 19 September 2024. https://synapse.patsnap.com/drug/c8a1d33533454c898fe14c16b96012e5.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 "Discontinued anxiolytic drugs (2009 - 2014)". Expert Opin Investig Drugs 24 (4): 557–573. April 2015. doi:10.1517/13543784.2014.998335. PMID 25557457.
- ↑ 4.0 4.1 4.2 4.3 4.4 "Non-peptidic δ opioid receptor agonists and antagonists (2000 - 2012)". Expert Opin Ther Pat 23 (9): 1181–1208. September 2013. doi:10.1517/13543776.2013.804066. PMID 23705966.
- ↑ "Novel Antidepressants in the Pipeline (Phase II and III): A Systematic Review of the US Clinical Trials Registry". Pharmacopsychiatry 55 (4): 193–202. July 2022. doi:10.1055/a-1714-9097. PMID 35045580.
- ↑ "Emerging drugs for major depressive disorder". Expert Opin Emerg Drugs 17 (1): 105–126. March 2012. doi:10.1517/14728214.2012.660146. PMID 22339643.
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