Chemistry:Deekonda2016
From HandWiki
Deekonda2016 is a piperidine-based opioid analgesic compound, developed through modification of the fentanyl scaffold and with similar potency to fentanyl. It was designed as a mixed μ/δ opioid agonist but is much more selective for the μ-opioid receptor, with a binding affinity of 4 nM.[1][2][3][4]
See also
- Brorphine
- Fentanyl tropane
- Phenampromide
- R6890
- Secofentanyl
- List of fentanyl analogues
References
- ↑ "Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands". Bioorganic & Medicinal Chemistry 23 (18): 6185–6194. September 2015. doi:10.1016/j.bmc.2015.07.071. PMID 26299827.
- ↑ "Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands". Bioorganic & Medicinal Chemistry 24 (2): 85–91. January 2016. doi:10.1016/j.bmc.2015.11.030. PMID 26712115.
- ↑ "Fentanyl Family at the Mu-Opioid Receptor: Uniform Assessment of Binding and Computational Analysis". Molecules 24 (4): 740. February 2019. doi:10.3390/molecules24040740. PMID 30791394.
- ↑ "Toward a Universal μ-Agonist Template for Template-Based Alignment Modeling of Opioid Ligands". ACS Omega 4 (17): 17457–17476. October 2019. doi:10.1021/acsomega.9b02244. PMID 31656918.
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