Chemistry:Isotocyanozene

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Isotocyanozene (5-cyano-isotodesnitazene) is a benzimidazole opioid analogue of isotonitazene which has been sold as a designer drug. It was first prospectively observed in a toxicological sample in Scotland, United Kingdom in 2025, and was presumed to have opioid effects.[1] It has been identified by the drug checking service CanTEST, Australia in September 2025 as an expected 'opioid' sample, and then later as an expected 'benzodiazepine' sample.[2][3] Its in vitro biological activity is close to that of fentanyl.[4]

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