Chemistry:Etomethazene
From HandWiki
Etomethazene (5-methyldesnitroetonitazene, 5-methyl etodesnitazene, Eto) is a benzimidazole derivative with opioid effects which has been sold as a designer drug over the internet since 2022, first being definitively identified in Sweden in January 2023.[1][2] It is an analogue of etonitazene where the nitro (NO2) group has been replaced by a methyl (CH3) group. It is less potent than etonitazene itself but still has around twice the potency of fentanyl.[3] Etomethazene has a relatively short duration of action of about 120 min.[4][5][6]
See also
- Etoacetazene
- Etocyanazene
- Etodesnitazene
- Etonitazepyne
- Isotonitazene
- Metonitazene
- List of benzimidazole opioids
References
- ↑ "In vitro structure-activity relationships and forensic case series of emerging 2-benzylbenzimidazole 'nitazene' opioids". Archives of Toxicology 98 (9): 2999–3018. June 2024. doi:10.1007/s00204-024-03774-7. PMID 38877156. Bibcode: 2024ArTox..98.2999D.
- ↑ "New psychoactive substances - the current situation in Europe". European Drug Report. European Union Drugs Agency (EUDA). 2024. https://www.euda.europa.eu/sites/default/files/pdf/31883_en.pdf?606797.
- ↑ Taoussi O, Carlier J, Gameli PS, Huppertz LM, Bambagiotti G, Tavoletta F, Tini A, Berardinelli D, Busardò FP, Auwärter V. 5-Methyl etodesnitazene human metabolism: LC-ESI±-HRMS/MS analysis (mono- and di-protonation) of human hepatocyte incubations and positive biospecimens. Anal Bioanal Chem. 2026 Apr 28. doi:10.1007/s00216-026-06472-8 PMID 42050027
- ↑ "Early signal alert: Emergence of online mentions of etomethazene". National Drug Early Warning System. University of Florida, New York University, and Florida Atlantic University. 1 July 2022. https://ndews.org/wordpress/files/2023/04/7.1.22.pdf.
- ↑ "5-methyl Etodesnitazene (citrate)". Caymanchem.com. https://www.caymanchem.com/product/36767/5-methyl-etodesnitazene-(citrate).
- ↑ "Klassificeringsdokument Narkotika. Etometazen (5-metyletodesnitazen)" (in Swedish). Folkhälsomyndigheten (The Public Health Authority). https://www.aklagare.se/globalassets/dokument/narkotikapreparat/e/etometazen2.pdf.
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