Chemistry:SR-14136
From HandWiki
SR-14136 is a synthetic opioid receptor agonist from the orphine series. It acts primarily as a highly potent agonist for the kappa opioid receptor, being around 10x more potent than the reference kappa agonist U-69593, and is also an agonist at the nociceptin receptor with only slightly lower potency. It has substantially weaker activity at the mu opioid receptor, at which it is a partial agonist.[1]
See also
- κ-Opioid receptor agonist
- J-113,397
- SR-17018
- Utopioid (drug class)
References
- ↑ "The design and synthesis of a novel quinolizidine template for potent opioid and opioid receptor-like (ORL1, NOP) receptor ligands". Bioorganic & Medicinal Chemistry Letters 14 (1): 181–185. 5 January 2004. doi:10.1016/j.bmcl.2003.09.068. PMID 14684324.
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