Chemistry:Tilapertin

From HandWiki

Tilapertin (INN), also known as AMG-747,[1] is a investigational drug which was being evaluated as an antipsychotic.[2]

Mechanism of action

Tilapertin appears to act via the blocking of the type 1 glycine transporter,[3] making it a glycine re-uptake inhibitor.

History

Two studies have been made in order to determine the safety of tilapertin and its potential as an add-on to anti-psychotic therapy in people with schizophrenia. These studies were later halted due to a case of Stevens–Johnson syndrome in one of the participants.[3]

See also

References

  1. ↑ "Tilapertin". PubChem. U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/25063875#section=Depositor-Supplied-Synonyms. 
  2. ↑ World Health Organization (2013). "International Nonproprietary Names for Pharmaceutical Substances (INN): Proposed INN: List 110". WHO Drug Information (World Health Organization) 27 (4). https://www.who.int/medicines/publications/druginformation/innlists/PL110.pdf. 
  3. ↑ 3.0 3.1 "Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia". Schizophrenia Research 182: 90–97. April 2017. doi:10.1016/j.schres.2016.10.027. PMID 27789188. 



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