Chemistry:N-Phenethyl-14-ethoxymetopon
From HandWiki
Short description: Opioid analgesic drug
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| Formula | C27H31NO4 |
| Molar mass | 433.548 g·mol−1 |
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N-Phenethyl-14-ethoxymetopon is a drug that is a derivative of metopon. It is a potent analgesic, around 60 times stronger than morphine and produces significantly less constipation.[1]
N-Phenethyl-14-ethoxymetopon acts as an agonist at both μ- and δ-opioid receptors, with a Ki of 0.16 nM at μ and 3.14 nM at δ.[2]
See also
- 14-Cinnamoyloxycodeinone
- 14-Phenylpropoxymetopon
- 7-PET
- MR-2096
- N-Phenethylnormorphine
- Phenomorphan
- RAM-378
- Ro4-1539
References
- ↑ "Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics". The AAPS Journal 8 (1): E118-25. March 2006. doi:10.1208/aapsj080114. PMID 16584118.
- ↑ "Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities". Journal of Medicinal Chemistry 48 (9): 3372–8. May 2005. doi:10.1021/jm040894o. PMID 15857143.
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