Chemistry:M320 (opioid)
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Short description: Chemical compound
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| Other names | (5α,6β,14β,18R)-17-(Cyclopropylmethyl)-18-[(2R)-2-hydroxy-5-methyl-2-hexanyl]-6-methoxy-7,8-didehydro-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol |
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| Formula | C30H41NO4 |
| Molar mass | 479.661 g·mol−1 |
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M320 is an extremely potent and long acting opioid. It produces long lasting narcosis in different animals, including mice, rats, cats, guinea pigs, dogs and monkeys.[1] M320 is a μ and κ-opioid receptor agonist.[2][3][4]
See also
References
- ↑ "The pharmacology of N-(cyclopropylmethyl)-19-isopentylnororvinol hydrochloride. A potent and long lasting central depressant". British Journal of Pharmacology and Chemotherapy 26 (2): 307–321. February 1966. doi:10.1111/j.1476-5381.1966.tb01910.x. PMID 4958020.
- ↑ "The effects of N-(cyclopropylmethyl)-19-isopentylnororvinol (M320), a potent agonist at kappa- and mu-opiate receptors, on urine excretion of rats". British Journal of Pharmacology 89 (4): 759–767. December 1986. doi:10.1111/j.1476-5381.1986.tb11180.x. PMID 3028550.
- ↑ "Studies of the effects of subacute treatment with N-(cyclopropylmethyl)-19-isopentylnororvinol (M320) on timing of parturition in the rat". British Journal of Pharmacology 95 (3): 777–782. November 1988. doi:10.1111/j.1476-5381.1988.tb11704.x. PMID 3207993.
- ↑ "Orvinols with mixed kappa/mu opioid receptor agonist activity". Journal of Medicinal Chemistry 56 (8): 3207–3216. April 2013. doi:10.1021/jm301543e. PMID 23438330.
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