Chemistry:Metonitazene
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| Formula | C21H26N4O3 |
| Molar mass | 382.464 g·mol−1 |
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Metonitazene is an analgesic compound related to etonitazene,[2][3] which was first reported in 1957,[4] and has been shown to have approximately 1000 times the potency of morphine by central routes of administration,[5] but if used orally it has been shown to have approximately 10 times the potency of morphine.[6]
Its effects are similar to other opioids such as fentanyl and heroin, including analgesia, euphoria, and sleepiness.[6][7] Adverse effects include vomiting, and respiratory depression that can potentially be fatal.[8] Because of high dependency potential and dangerous adverse effects it has never been introduced into pharmacotherapy. It is instead commonly used in the illicit manufacture of counterfeit-OxyContin opioid pills.
Legal status
In the United States, metonitazene is a Schedule I controlled substance under the Controlled Substances Act.
Metonitazene is not controlled under the 1971 Convention on Psychotropic Substances; however, in many countries possession or intent to sell for human consumption might be prosecuted under several analog acts.
See also
References
- ↑ Riksdagsförvaltningen. "Förordning (1992:1554) om kontroll av narkotika Svensk författningssamling 1992:1992:1554 t.o.m. SFS 2021:301 - Riksdagen". https://www.riksdagen.se/sv/dokument-lagar/dokument/svensk-forfattningssamling/forordning-19921554-om-kontroll-av-narkotika_sfs-1992-1554.
- ↑ "Synthesis, Chemical Characterization, and μ-Opioid Receptor Activity Assessment of the Emerging Group of "Nitazene" 2-Benzylbenzimidazole Synthetic Opioids". ACS Chemical Neuroscience 12 (7): 1241–1251. April 2021. doi:10.1021/acschemneuro.1c00064. PMID 33759494. https://biblio.ugent.be/publication/8714061.
- ↑ "DARK Classics in Chemical Neuroscience: Etonitazene and Related Benzimidazoles". ACS Chemical Neuroscience 12 (7): 1072–1092. April 2021. doi:10.1021/acschemneuro.1c00037. PMID 33760580.
- ↑ "[Synthesis of analgesically active benzimidazole derivatives with basic substitutions]". Experientia 13 (10): 400–401. October 1957. doi:10.1007/bf02161116. PMID 13473817.
- ↑ "Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-nenzyl-nitro-benzimidazolen" (in en). Helvetica Chimica Acta 43 (4): 1032–1046. 1960. doi:10.1002/hlca.19600430412.
- ↑ 6.0 6.1 "[New powerful analgetics and their clinical testing]". Klinische Wochenschrift 36 (20): 960–963. October 1958. doi:10.1007/bf01486702. PMID 13612082.
- ↑ "Metonitazene in the United States-Forensic toxicology assessment of a potent new synthetic opioid using liquid chromatography mass spectrometry". Drug Testing and Analysis 13 (10): 1697–1711. October 2021. doi:10.1002/dta.3115. PMID 34137194.
- ↑ "Acute Intoxications and Fatalities Associated With Benzimidazole Opioid (Nitazene Analog) Use: A Systematic Review". Therapeutic Drug Monitoring 44 (4): 494–510. August 2022. doi:10.1097/FTD.0000000000000970. PMID 35149665.
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