Chemistry:TAN-821
From HandWiki
TAN-821 is an opioid drug which was originally reported as an agonist for the putative ε-opioid receptor, however this is now thought not to be a separate opioid receptor in its own right but is more likely a heteromer made from hybridisation of known opioid receptor subunits. It has subsequently been shown to have potent affinity for the kappa opioid receptor.[1][2][3][4][5]
See also
References
- ↑ "Drug design and synthesis of epsilon opioid receptor agonist: 17-(cyclopropylmethyl)-4,5alpha-epoxy-3,6beta-dihydroxy-6,14-endoethenomorphinan-7alpha-(N-methyl-N-phenethyl)carboxamide (TAN-821) inducing antinociception mediated by putative epsilon opioid receptor". Bioorganic & Medicinal Chemistry 12 (15): 4133–4145. August 2004. doi:10.1016/j.bmc.2004.05.024. PMID 15246090.
- ↑ "Rational drug design and synthesis of a selective opioid receptor antagonist on the basis of the accessory site concept". Bioorganic & Medicinal Chemistry Letters 14 (16): 4241–4243. August 2004. doi:10.1016/j.bmcl.2004.06.004. PMID 15261278.
- ↑ "Rational drug design of selective epsilon opioid receptor agonist TAN-821 and antagonist TAN-1014". Current Medicinal Chemistry 13 (10): 1109–1118. 2006. doi:10.2174/092986706776360851. PMID 16719773.
- ↑ "Novel rearrangement reaction of a 6,14-endoethanomorphinan derivative to a benzomorphan derivative". Tetrahedron 65 (25): 4808–4813. 2009. doi:10.1016/j.tet.2009.04.055.
- ↑ "Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists". Bioorganic & Medicinal Chemistry 18 (12): 4446–4452. June 2010. doi:10.1016/j.bmc.2010.04.069. PMID 20478711.
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