Chemistry:TL 2636
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| Formula | C28H37NO4 |
| Molar mass | 451.607 g·mol−1 |
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TL 2636 (M-125) is an opioid drug derived from thebaine, one of the bridged oripavine family of drugs known as the Bentley compounds which includes drugs such as buprenorphine and etorphine. TL 2636 is closely related to etorphine and is a similarly potent opioid analgesic and sedative, but at low doses is characterised by producing pronounced nausea and vomiting, with a long duration of action. It was investigated as a potential incapacitating agent but was not successful due to a poor therapeutic index.[1][2][3][4][5]
See also
References
- ↑ "Novel analgesics and molecular rearrangements in the morphine-thebaine group. 3. Alcohols of the 6,14-endo-ethenotetrahydrooripavine series and derived analogs of N-allylnormorphine and -norcodeine". Journal of the American Chemical Society 89 (13): 3281–3292. June 1967. doi:10.1021/ja00989a032. PMID 6042764. Bibcode: 1967JAChS..89.3281B.
- ↑ "An Oripavine Derivative (TL2636) as a Potential Incapacitating Agent.". Porton Technical Paper. 1963. 835, PRO/WO189/357.
- ↑ "The UK's Search for an Incapacitating ('Non-Lethal') Chemical Agent in the 1960s.". Bradford Project on Strengthening the Biological and Toxin Weapons Convention (BTWC) (University of Bradford). January 2006. https://bradscholars.brad.ac.uk/server/api/core/bitstreams/b9cfa584-78f9-455e-9b7a-40b44dad7d4b/content.
- ↑ "Incapacitating Biochemical Weapons". The Nonproliferation Review 13 (2): 151–188. 2006. doi:10.1080/10736700601012029.
- ↑ "Creating a 'Father Confessor': the origins of research ethics committees in UK military medical research, 1950-1970. Part I, context and causes". Journal of the Royal Army Medical Corps 165 (4): 284–290. August 2019. doi:10.1136/jramc-2019-001206. PMID 31164389.
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