Chemistry:Etodesnitazene
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Short description: Chemical compound
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| Formula | C22H29N3O |
| Molar mass | 351.494 g·mol−1 |
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Etodesnitazene (Desnitroetonitazene, Etazen, Etazene, Etazone) is a benzimidazole derived opioid analgesic drug, which was originally developed in the late 1950s alongside etonitazene and a range of related derivatives.[1] It is many times less potent than etonitazene itself, but still 70x more potent than morphine in animal studies. Corresponding analogues where the N,N-diethyl group is replaced by piperidine or pyrrolidine rings also retain significant activity (10x and 20x morphine respectively).[2] Etodesnitazene has been sold as a designer drug,[3] first being identified in both Poland and Finland in March 2020.[4][5]
See also
- Brorphine
- Etonitazepyne
- Etoacetazene
- Etocyanazene
- Etomethazene
- Isotonitazene
- Metonitazene
- Metodesnitazene
- MCHB-1
- List of benzimidazole opioids
References
- ↑ "DARK Classics in Chemical Neuroscience: Etonitazene and Related Benzimidazoles". ACS Chemical Neuroscience 12 (7): 1072–1092. April 2021. doi:10.1021/acschemneuro.1c00037. PMID 33760580.
- ↑ "Benzimidazol-Derivate und verwandte Heterocyclen. II. Synthese von 1-Aminoalkyl-2-benzyl-benzimidazolen." (in German). Helvetica Chimica Acta 43 (3): 800–809. 1960. doi:10.1002/hlca.19600430323.
- ↑ "Etazene (N,N-diethyl-2-{[(4-ethoxyphenyl)methyl]-1H-benzimidazol-1-yl}-ethan-1-amine (dihydrochloride)): a novel benzimidazole opioid NPS identified in seized material: crystal structure and spectroscopic characterization". Forensic Toxicology. 2020. doi:10.1007/s11419-020-00552-9. ISSN 1860-8973.
- ↑ "Etazene (N,N-diethyl-2-{[(4-ethoxyphenyl)methyl]-1H-benzimidazol-1-yl}-ethan-1-amine (dihydrochloride)): a novel benzimidazole opioid NPS identified in seized material: crystal structure and spectroscopic characterization" (in en). Forensic Toxicology 39 (1): 146–155. January 2021. doi:10.1007/s11419-020-00552-9. ISSN 1860-8965.
- ↑ "EU Early Warning System Situation Report. Situation report 1". European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). June 2020. https://www.aekwien.at/documents/263869/449604/200629_EU+EARLY+WARNING+SYSTEM+SITUATION+REPORT+June.pdf.
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