Chemistry:N-Desethylisotonitazene
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| Routes of administration | Oral, intransal, vaporized |
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| Formula | C21H26N4O3 |
| Molar mass | 382.464 g·mol−1 |
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N-Desethylisotonitazene (norisotonitazene) is a benzimidazole opioid with potent analgesic effects which has been sold as a designer drug. It was first identified in 2023 as an active metabolite of the closely related compound isotonitazene, and was found to have similar potency. It is one of the strongest benzimidazole opioids discovered, with an analgesic strength 20 times stronger than fentanyl.
Starting in 2023, it has become an increasingly widespread drug of abuse in its own right, linked to numerous overdose cases, and may be considered an analog of the schedule 1 drug metonitazene. In October 2023, the DEA published an intent to temporarily schedule etonitazepipne and N-desethylisotonitazene. As of April 2024, it is not yet controlled in the United States.[1][2][3][4][5][6][7]
See also
References
- ↑ "Isotonitazene Quantitation and Metabolite Discovery in Authentic Forensic Casework". Journal of Analytical Toxicology 44 (6): 521–530. July 2020. doi:10.1093/jat/bkaa016. PMID 32091095.
- ↑ "Synthesis, Chemical Characterization, and μ-Opioid Receptor Activity Assessment of the Emerging Group of "Nitazene" 2-Benzylbenzimidazole Synthetic Opioids". ACS Chemical Neuroscience 12 (7): 1241–1251. April 2021. doi:10.1021/acschemneuro.1c00064. PMID 33759494. https://biblio.ugent.be/publication/8714061.
- ↑ "A Forward-Thinking Approach to Addressing the New Synthetic Opioid 2-Benzylbenzimidazole Nitazene Analogs by Liquid Chromatography-Tandem Quadrupole Mass Spectrometry (LC-QQQ-MS)". Journal of Analytical Toxicology 46 (3): 221–231. March 2022. doi:10.1093/jat/bkab117. PMID 34792157.
- ↑ "Comparative neuropharmacology of structurally distinct non-fentanyl opioids that are appearing on recreational drug markets worldwide". Drug and Alcohol Dependence 249. May 2023. doi:10.1016/j.drugalcdep.2023.109939. PMID 37276825.
- ↑ "Mu-opioid receptor selective superagonists produce prolonged respiratory depression". iScience 26 (7). 2023. doi:10.1016/j.isci.2023.107121. PMID 37416459. Bibcode: 2023iSci...26j7121M.
- ↑ "Opioid 20x More Potent than Fentanyl Detected in Pennsylvania, Florida.". Forensic. 30 January 2023. https://www.forensicmag.com/594031-Opioid-20x-More-Potent-than-Fentanyl-Detected-in-Pennsylvania-Florida/.
- ↑ "Federal Register :: Request Access". 25 October 2023. https://www.federalregister.gov/documents/2023/10/25/2023-23379/schedules-of-controlled-substances-temporary-placement-of-n-desethyl-isotonitazene-and-n-piperidinyl.
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