Chemistry:N-Desethylisotonitazene
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| Formula | C21H26N4O3 |
| Molar mass | 382.464 g·mol−1 |
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N-Desethylisotonitazene (Norisotonitazene) is a benzimidazole derivative with potent opioid effects which has been sold as a designer drug. It was first identified as an active metabolite of the related compound isotonitazene, but was unexpectedly found to be similar potency compared to the parent compound, and is among the most potent opioid agonists in this family, around 20 times stronger than fentanyl. It has become an increasingly widespread drug of abuse in its own right, linked to numerous cases of drug overdose,and may be considered an analog of a schedule 1 drug in the US. On October 25 an intent to temporarily schedule Etonitazepipne and N-desethyl Isotonitazene was published. So on November 24 a month after publishing intent, it will most likely be placed in schedule 1.[1][2][3][4][5][6]
See also
References
- ↑ "Isotonitazene Quantitation and Metabolite Discovery in Authentic Forensic Casework". Journal of Analytical Toxicology 44 (6): 521–530. July 2020. doi:10.1093/jat/bkaa016. PMID 32091095.
- ↑ "Synthesis, Chemical Characterization, and μ-Opioid Receptor Activity Assessment of the Emerging Group of "Nitazene" 2-Benzylbenzimidazole Synthetic Opioids". ACS Chemical Neuroscience 12 (7): 1241–1251. April 2021. doi:10.1021/acschemneuro.1c00064. PMID 33759494. https://biblio.ugent.be/publication/8714061.
- ↑ "A Forward-Thinking Approach to Addressing the New Synthetic Opioid 2-Benzylbenzimidazole Nitazene Analogs by Liquid Chromatography-Tandem Quadrupole Mass Spectrometry (LC-QQQ-MS)". Journal of Analytical Toxicology 46 (3): 221–231. March 2022. doi:10.1093/jat/bkab117. PMID 34792157.
- ↑ "Comparative neuropharmacology of structurally distinct non-fentanyl opioids that are appearing on recreational drug markets worldwide". Drug and Alcohol Dependence 249: 109939. May 2023. doi:10.1016/j.drugalcdep.2023.109939. PMID 37276825.
- ↑ Malcolm NJ, Palkovic B, Sprague DJ, Calkins MM, Lanham JK, Halberstadt AL, Stucke AG, McCorvy JD. Mu-opioid Receptor Selective Superagonists Produce Prolonged Respiratory Depression. ISCIENCE (2023) doi:10.1016/j.isci.2023.107121
- ↑ "Opioid 20x More Potent than Fentanyl Detected in Pennsylvania, Florida.". Forensic. 30 January 2023. https://www.forensicmag.com/594031-Opioid-20x-More-Potent-than-Fentanyl-Detected-in-Pennsylvania-Florida/.
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