Chemistry:Protonitazepyne
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Protonitazepyne (N-pyrrolidino protonitazene) is a benzimidazole derivative with opioid effects, which has been sold as a designer drug over the internet, first being mentioned in mid 2022 and definitively identified in drug seizures in Canada in early 2023 and Ireland in late 2023.[1] It has since been identified by CanTEST in May 2024 in Australia[2] and in late 2025 in Brazil by the State University of Campinas poison control center.[3]
It is an analogue of protonitazene where the N,N-diethyl group has been substituted for pyrrolidine group. While formal studies into its pharmacology have yet to be carried out, it is has an in vitro potency approximately 350x times that of morphine.[4]
See also
- Isotonitazene
- Isotonitazepyne
- Metonitazene
- Etomethazene
- Etonitazepipne
- List of benzimidazole opioids
References
- ↑ "Identification of N-pyrrolidino protonitazene in powders sold as heroin and associated with overdose clusters in Dublin and Cork, Ireland". Drug Testing and Analysis 17 (3): 350–357. May 2024. doi:10.1002/dta.3707. PMID 38769669.
- ↑ "N-pyrrolidino protonitazene found in brown powder sample" (in en). The Know. Australia: National Clinical Centre for Research of Emerging Drugs (NCCRED). 2024-05-18. https://theknow.org.au/alerts_warnings/n-pyrrolidino-protonitazene-found-in-brown-powder-sample/.
- ↑ "Unicamp identifica nova droga 50 vezes mais potente que fentanil pela 1ª vez no Brasil; entenda" (in pt-br). G1. 2025-10-12. https://g1.globo.com/sp/campinas-regiao/noticia/2025/10/12/unicamp-identifica-nova-droga-50-vezes-mais-potente-que-fentanil-pela-1a-vez-no-brasil-entenda.ghtml.
- ↑ "In vitro structure-activity relationships and forensic case series of emerging 2-benzylbenzimidazole 'nitazene' opioids". Archives of Toxicology 98 (9): 2999–3018. September 2024. doi:10.1007/s00204-024-03774-7. PMID 38877156. Bibcode: 2024ArTox..98.2999D.
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