Chemistry:Protonitazene
From HandWiki
Short description: Chemical compound
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| Formula | C23H30N4O3 |
| Molar mass | 410.518 g·mol−1 |
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Protonitazene is a benzimidazole derivative with potent opioid effects which has been sold over the internet as a designer drug since 2019, and has been identified in various European countries, as well as Canada, the USA and Australia.[1] It has been linked to numerous cases of drug overdose, and is a Schedule I drug in the USA.[2][3][4][5][6]
It was developed by a Swiss pharmaceutical company in the 1950s as an alternative to morphine, but was never adopted due to severe side effects.[7]
See also
References
- ↑ "New Synthetic Opioids: Clinical Considerations and Dangers". Pain and Therapy 12 (2): 399–421. April 2023. doi:10.1007/s40122-023-00481-6. PMID 36826742.
- ↑ "Intoxications in an Australian Emergency Department Involving 'Nitazene' Benzylbenzimidazole Synthetic Opioids (Etodesnitazene, Butonitazene and Protonitazene)". Journal of Analytical Toxicology 47 (1): e6–e9. August 2022. doi:10.1093/jat/bkac062. PMID 35983900.
- ↑ "Analysis of highly potent synthetic opioid nitazene analogs and their positional isomers". Drug Testing and Analysis 15 (4): 449–457. November 2022. doi:10.1002/dta.3415. PMID 36437623.
- ↑ "Proliferation of Novel Synthetic Opioids in Postmortem Investigations After Core-Structure Scheduling for Fentanyl-Related Substances". The American Journal of Forensic Medicine and Pathology 43 (4): 315–327. December 2022. doi:10.1097/PAF.0000000000000787. PMID 36103391.
- ↑ "A Forward-Thinking Approach to Addressing the New Synthetic Opioid 2-Benzylbenzimidazole Nitazene Analogs by Liquid Chromatography-Tandem Quadrupole Mass Spectrometry (LC-QQQ-MS)". Journal of Analytical Toxicology 46 (3): 221–231. March 2022. doi:10.1093/jat/bkab117. PMID 34792157.
- ↑ "21 CFR Part 1308. [Docket No. DEA–900 Schedules of Controlled Substances: Temporary Placement of Butonitazene, Etodesnitazene, Flunitazene, Metodesnitazene, Metonitazene, N-Pyrrolidino etonitazene, and Protonitazene in Schedule I."]. Federal Register (Drug Enforcement Administration) 87 (70): 21556. 12 April 2022. https://www.govinfo.gov/content/pkg/FR-2022-04-12/pdf/2022-07640.pdf.
- ↑ Faugstad, Sebastian (23 November 2022). "20-åring døde etter inntak av nytt, livsfarlig rusmiddel" (in nb-NO). https://www.nrk.no/osloogviken/20-aring-dode-etter-inntak-av-nytt_-livsfarlig-rusmiddel-1.16184946. "Protonitazen er et syntetisk opioid som ble utviklet av et sveitsisk legemiddelselskap på 50-tallet. Det var ment som et alternativ til morfin, men på grunn av alvorlige bivirkninger ble stoffet aldri tatt i bruk."
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