Chemistry:R-5260
From HandWiki
R-5260 is an opioid drug from the orphine series, which is a derivative of the opioid analgesic norpipanone, but with the piperidine ring fused with a spiro heterocycle. It was developed by Janssen Pharmaceutica, and is a highly potent opioid around 10x the potency of fentanyl. It is related to other potent opioid derivatives such as dipipanone, bezitramide, R-4066 and spirochlorphine, and is also related to dopamine antagonist neuroleptic drugs such as spiperone and fluspirilene, although R-5260 does not have any dopamine antagonist activity itself.[1][2]
See also
- Spirodecanone
References
- ↑ "Differentiation of opiate and neuroleptic receptor binding in rat brain". European Journal of Pharmacology 43 (3): 253–267. June 1977. doi:10.1016/0014-2999(77)90025-5. PMID 194781.
- ↑ "Differentiation of solubilized dopamine receptors from spirodecanone binding sites in rat striatum". FEBS Letters 121 (1): 133–138. November 1980. doi:10.1016/0014-5793(80)81282-8. PMID 6161839. Bibcode: 1980FEBSL.121..133G.
 | 0.00  (0 votes) |
