Biology:CD6
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CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene.[1][2]
Function
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation.[1]
Clinical significance
Certain alleles of this gene may be associated with susceptibility to multiple sclerosis.[3][4]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: CD6 CD6 molecule". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=923.
- ↑ "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213–20. 1995. doi:10.1084/jem.181.6.2213. PMID 7760007.
- ↑ "Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci". Nat. Genet. 41 (7): 776–82. 2009. doi:10.1038/ng.401. PMID 19525953.
- ↑ "The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation". J. Immunol. 187 (6): 3286–91. 2011. doi:10.4049/jimmunol.1100626. PMID 21849685.
Further reading
- "The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins". J. Exp. Med. 174 (4): 949–52. 1991. doi:10.1084/jem.174.4.949. PMID 1919444.
- "Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule". J. Biol. Chem. 266 (11): 7137–43. 1991. doi:10.1016/S0021-9258(20)89621-5. PMID 2016320.
- "Assignment of gene coding human T-cell differentiation antigen, Tp120, to chromosome 11". Somat. Cell Mol. Genet. 11 (3): 217–22. 1985. doi:10.1007/BF01534678. PMID 3923629.
- "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site". J. Biol. Chem. 270 (31): 18187–90. 1995. doi:10.1074/jbc.270.31.18187. PMID 7543097.
- "Human CD6 possesses a large, alternatively spliced cytoplasmic domain". Eur. J. Immunol. 25 (10): 2765–9. 1995. doi:10.1002/eji.1830251008. PMID 7589069.
- "Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors". J. Exp. Med. 177 (1): 219–23. 1993. doi:10.1084/jem.177.1.219. PMID 7678115.
- "Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms". J. Immunol. 158 (3): 1149–56. 1997. doi:10.4049/jimmunol.158.3.1149. PMID 9013954.
- "Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains". Eur. J. Immunol. 27 (11): 2971–80. 1998. doi:10.1002/eji.1830271133. PMID 9394826.
- "CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes". Immunol. Lett. 58 (1): 9–14. 1998. doi:10.1016/S0165-2478(97)02707-7. PMID 9436462.
- "The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells". J. Biol. Chem. 278 (10): 8564–71. 2003. doi:10.1074/jbc.M209591200. PMID 12473675.
- "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. 2003. doi:10.1074/jbc.M210455200. PMID 12493773.
- "The lymphocyte receptor CD6 interacts with syntenin-1, a scaffolding protein containing PDZ domains". J. Immunol. 175 (3): 1406–14. 2005. doi:10.4049/jimmunol.175.3.1406. PMID 16034076.
- "Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens". J. Immunol. 177 (2): 877–84. 2006. doi:10.4049/jimmunol.177.2.877. PMID 16818742.
- "Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor". J. Immunol. 177 (2): 1152–9. 2006. doi:10.4049/jimmunol.177.2.1152. PMID 16818773.
- "CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76". Mol. Cell. Biol. 26 (17): 6727–38. 2006. doi:10.1128/MCB.00688-06. PMID 16914752.
- "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse". J. Immunol. 178 (7): 4351–61. 2007. doi:10.4049/jimmunol.178.7.4351. PMID 17371992.
- "CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock". Proc. Natl. Acad. Sci. U.S.A. 104 (28): 11724–9. 2007. doi:10.1073/pnas.0702815104. PMID 17601777. Bibcode: 2007PNAS..10411724S.
External links
- CD6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CD6 genome location and CD6 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: P30203 (Human T-cell differentiation antigen CD6) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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