Biology:SIRPG
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene.[1][2][3] SIRPG has also recently been designated CD172G (cluster of differentiation 172G).
The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.[3]
References
- ↑ "Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family". J Hum Genet 45 (6): 378–82. Jan 2001. doi:10.1007/s100380070013. PMID 11185750.
- ↑ "A nomenclature for signal regulatory protein family members". J Immunol 175 (12): 7788–9. Dec 2005. doi:10.4049/jimmunol.175.12.7788. PMID 16339511.
- ↑ 3.0 3.1 "Entrez Gene: SIRPG signal-regulatory protein gamma". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55423.
Further reading
- "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature 386 (6621): 181–6. 1997. doi:10.1038/386181a0. PMID 9062191. Bibcode: 1997Natur.386..181K.
- "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family". J. Immunol. 173 (4): 2562–70. 2004. doi:10.4049/jimmunol.173.4.2562. PMID 15294972.
- "Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation". Blood 105 (6): 2421–7. 2006. doi:10.1182/blood-2004-07-2823. PMID 15383453.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Signal-regulatory protein gamma (SIRPG)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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