Biology:CD248
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Endosialin is a protein that in humans is encoded by the CD248 gene.[1][2][3]
Endosialin is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell–cell adhesion processes but also in host defence. This family comprise three other members, CLEC14A, CD93 and Thrombomodulin the latter of which are better characterized. [4]
The function of endosialin remains elusive, but its expression has been associated with angiogenesis in the embryo and uterus and in tumor development and growth.[5]
See also
References
- ↑ "Genes expressed in human tumor endothelium". Science 289 (5482): 1197–202. Aug 2000. doi:10.1126/science.289.5482.1197. PMID 10947988. Bibcode: 2000Sci...289.1197S.
- ↑ "Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium". J Biol Chem 276 (10): 7408–14. May 2001. doi:10.1074/jbc.M009604200. PMID 11084048.
- ↑ "Entrez Gene: CD248 CD248 molecule, endosialin". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57124.
- ↑ "C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation.". FEBS Journal 286 (17): 3299–3332. 2019. doi:10.1111/febs.14985. PMID 31287944.
- ↑ "Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis.". Cancer Immun 6: 10. 2006. PMID 16875435.
Further reading
- "Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer.". Proc. Natl. Acad. Sci. U.S.A. 89 (22): 10832–6. 1992. doi:10.1073/pnas.89.22.10832. PMID 1438285. Bibcode: 1992PNAS...8910832R.
- "Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo.". J. Biol. Chem. 276 (42): 38795–807. 2001. doi:10.1074/jbc.M105241200. PMID 11489895.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Human endosialin (tumor endothelial marker 1) is abundantly expressed in highly malignant and invasive brain tumors.". J. Neuropathol. Exp. Neurol. 63 (12): 1274–83. 2005. doi:10.1093/jnen/63.12.1274. PMID 15624764.
- "Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium.". FEBS Lett. 579 (12): 2569–75. 2005. doi:10.1016/j.febslet.2005.03.071. PMID 15862292. http://pure-oai.bham.ac.uk/ws/files/22010413/MacFadyen_et_al_1_s2.0_S0014579305004230_main.pdf.
- "Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin.". Cancer Immun. 5: 10. 2006. PMID 16076089.
- "Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration.". Proc. Natl. Acad. Sci. U.S.A. 104 (46): 17965–70. 2008. doi:10.1073/pnas.0705647104. PMID 17986615.
- "C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation.". FEBS Journal 286 (17): 3299–3332. 2019. doi:10.1111/febs.14985. PMID 31287944.
External links
- CD248+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CD248 genome location and CD248 gene details page in the UCSC Genome Browser.
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