Biology:CEACAM8

Short description: Mammalian protein found in Homo sapiens

Generic protein structure example

Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8) also known as CD66b (Cluster of Differentiation 66b), is a member of the carcinoembryonic antigen (CEA) gene family. Its main function is cell adhesion, cell migration, and pathogen binding.

Use

CEACAM8 is expressed exclusively on granulocytes and used as granulocyte marker.

See also

• Cluster of differentiation

Further reading

• "Identification of three new genes and estimation of the size of the carcinoembryonic antigen family.". Genomics 14 (2): 384–90. 1992. doi:10.1016/S0888-7543(05)80230-7. PMID 1427854. 
• "A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains.". J. Biol. Chem. 266 (13): 7995–8001. 1991. doi:10.1016/S0021-9258(18)92930-3. PMID 2022629. 
• "Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow.". Cancer Res. 50 (20): 6534–9. 1990. PMID 2208113. 
• "Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family.". Biochem. Biophys. Res. Commun. 166 (3): 1063–71. 1990. doi:10.1016/0006-291X(90)90975-S. PMID 2306228. 
• "Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes.". Blood 91 (2): 663–72. 1998. doi:10.1182/blood.V91.2.663. PMID 9427723. 
• "Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids.". Scand. J. Immunol. 50 (4): 433–9. 1999. doi:10.1046/j.1365-3083.1999.00602.x. PMID 10520185. 
• "Extracellular N-domain alone can mediate specific heterophilic adhesion between members of the carcinoembryonic antigen family, CEACAM6 and CEACAM8.". Biochem. Biophys. Res. Commun. 278 (3): 564–8. 2001. doi:10.1006/bbrc.2000.3858. PMID 11095950. 
• "Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes.". J. Immunol. 168 (10): 5139–46. 2002. doi:10.4049/jimmunol.168.10.5139. PMID 11994468. 
• "Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes.". J. Immunol. Methods 270 (1): 27–35. 2002. doi:10.1016/s0022-1759(02)00215-6. PMID 12379336. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. 2004. doi:10.1038/nature02399. PMID 15057824. Bibcode: 2004Natur.428..529G. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.". J. Proteome Res. 5 (6): 1493–503. 2006. doi:10.1021/pr050492k. PMID 16740002. 

External links

• CEACAM8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CEACAM8 genome location and CEACAM8 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.